Bio-Synthesis offer DOTA oligonucleotide labeling service. Macrocyclic labels such as 1,4,7,10-tetraazacyclododecane-1,4,7-tetraacetic acid, DOTA, containing four acetic acid carboxylate groups off the four nitrogens of its twelve atom cyclic structure, is capable of modifying proteins and binding radioactive metal ions in strong coordination complexes of up to eight dative bonds.  DOTA labeled oligo are often  used as organic ligands in magnetic resonance imaging (MRI), single photon emission computed tomography (SPECT) or in application using target-specific radiopharmaceuticals.

DOTA chelator can be attached to an oligo at any position the use of different bifunctional cross linker.  Dual HPLC purification is highly recommended.

Contact us for DOTA Metal Chelator oligonucleotide labeling services or visit Chelator Bioconjugation Services for details

Product Information


Product Name:

DOTA, Tetraazacyclododecane-1,4,7,10-tetraacetic acid


Mecrocyclic Chelation, Fluorescent Metal Senor, Molecular Imaging

Modification Code:



Bio-Synthesis Inc. Oligo Structure


dual HPLC required

Delivery Format:


Shipping Conditions:

Room Temperature

Storage Conditions:

-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.