The Oyster®-488 fluorophore can be incorporated at any position within an Oligonucleotide. Oyster-488 is a rhodamine based dye exhibiting a high photostability and quantum yield as well as containing a single negative charge. The Oyster®-488 fluorophore is well suited for replacing Cy2, Alexa Fluor® 488, Dylight® 488 fluorophores in applications such as microarray and FISH.

A primary amine modified oligonucleotide allows covalent attachment of the Oyster 488 fluorophore via NHS conjugation chemistry. However, other cross-linking chemistries are also available depending on particular project specifications. After oligonucleotide synthesis and dye conjugation, a dual HPLC purification is used to remove failure sequences and excessive dye quantitatively to obtain a full length labeled oligonucleotide.

Product Information


Product Name:

Oyster® 488 Fluorescent Dye Oligo Labeling


Fluorescent Dye

Modification Code:


Formula Weight:

~ 1200

Excitation (nm):


Emission (nm):


Extinction Coefficient, ε(λ):

80,000 M-1 x cm-1


Bio-Synthesis Inc. Oligo Structure



Delivery Format:

Lyophilized; Protect from light

Shipping Conditions:

Room Temperature

Storage Conditions:

-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.