Enhanced Diagnostic Tools
Bio-Synthesis is a contract research and manufacturing organization founded in 1984. We specialize in the development and manufacturing of Genomics and Proteomic Products with emphasis on:
Bio-synthesis is a biology contract manufacturer of high quality nucleic acids, peptides and other molecular biology products for the research, diagnostic and therapeutic industries. Bio-Synthesis operates an ISO 9001 certified facility and is compliant with 21 CFR 210/211 and 21 CFR 820. Our solutions help advance drug discovery and bio-medical research. Founded in 1984, Bio-Synthesis is a privately held firm based in Lewisville, Texas.
Bio-Synthesis is a provider of Custom Peptide Synthesis for the life science research community since 1984. We offer a complete range of peptide synthesis services ranging from bulk API peptides to high throughput library peptides and array peptide preparation. Custom Peptides Synthesis is performed to produce research-grade or bulk API polypeptides. We specialize in both, liquid phase and solid phase Fmoc-chemistry. Liquid Phase Peptide Synthesis is used for the synthesis of very short peptides such as dipeptides, while large-scale Solid Phase Peptide Synthesis is well suited for preparing biologically active peptides including long, difficult and hydrophobic peptides. Bio-Synthesis also provides a large number of peptide modifications as well as custom peptides for diagnostic and therapeutic applications.
Bio-Synthesis is a provider of Custom Oligo Synthesis services. Oligonucleotides are synthesized as unmodified or modified chemical structures with defined sequences using a procedure known as Phosphoramidite solid-phase synthesis. Oligos which are synthesized using solid-phase phosphoramidite chemistry are often purified by high performance liquid chromatography (HPLC) or PAGE to achieve the desired purity. Synthetic DNA or RNA oligonucleotides obtained by solid-phase synthesis are employed in a majority of molecular biology applications such as PCR, real-time PCR, sequencing, site directed mutagenesis, single nucleotide polymorphism (SNP) assays, microarrays and various therapeutic applications.
As a pioneer in oligonucleotide synthesis, Bio-Synthesis has been pursuing the development of new oligonucleotide-based techniques that can produce compounds with superior binding affinity and chemical/biological stability. As such, Bio-Synthesis has introduced a third generation of nucleic acid analogs, Bridged Nucleic Acid (BNA). These are RNA analogues which can be synthesized and spiked with DNA or RNA in order to modify the formation of nucleic acid helices.
Phospho-peptides, Linkers, Spacers, Methylation, etc.
PEGylation, Cyclization, Lipopeptides, Glycosylation
Biotin, Fluorescein, Dyes, Stable Isotopes, etc.
All D-Amino Acids, Homo Amino Acids, N-methyl, Alpha, Beta, Gamma Amino Acids, Citrulline, Ornithine, Hydroxyproline, Pyroglutamic Acid
Custom RNA Transcription Synthesis (>5000 nt.) includes non-coding or capped and polyadenylated mRNA using plasmid DNA templates, PCR products, oligonucleotides or cDNA. These RNA/mRNA transcripts are ideal for diagnostic and therapeutic pre-clinical trials.