| |
Bio-Synthesis custom bioconjugation services provide personalized solutions designed to supply researchers with the widest choice of tools to support their studies. As a recognized leader in providing biconjugation services, Bio-Synthesis custom product offerings include the modification of biopolymers or other biopolymers covalently linked through chemical or biochemical methods. Molecules we work with include nucleic acids and their analogs, peptides and their mimetics, proteins, antibodies and their fragments, enzymes, quenchers or fluorophores, avidin/streptavidin, solid support and other biologically active molecules. These bioconjugates are delivered by scientists with deep expertise in synthesis and bioconjugation chemistries and biology with a special focus on synthetic organic chemistry and biochemistry. Bio-Synthesis custom products are backed by customer care delivered by highly-qualified BSI technical and application support personnel. |
|
| |
| Our Capabilities |
We are not only capable of synthesizing synthetic molecules but also able to provide various
bioconjugation
systems for specific intended applications. Whether it is for tagging proteins to make them chromogenic or fluorescent, labeling molecules with biospecific ligands for subsequent affinity interactions, or cross linking two or more substances to create uniquely active conjugates, the choices are available in our laboratory. Our chemist will examine each project carefully, and customize a conjugation procedure on the basis of their chemical reactivities and other chemical properties that affect their behavior during the conjugation process. This results in products that meet the specifications of the client. |
| |
| Characterization |
| Our sizeable investment in state-of-the-art analytical equipment provides industry-leading tools to develop and monitor our process. Complementary techniques, such as analytical chromatography and electrophoresis, are routinely used to verify that specifications are met. Sometimes, if the biopolymer is not too massive, Mass Spectroscopy can be used to determine its molecular weight. However, unless a crystal structure is available or a single unique functional group was used for conjugation, it may be difficult to know the exact conjugation site and the molar ratio of the reactants. Because of this complexity and difficulty, the effort required assessing the composition and purity of a bioconjugate depends largely on the requirements and rigor of the downstream research. |
| |
|
