New nucleic acid diagnostic tool with enhanced hybridization and quantification power.
Shivarov et al. published their work using BNA-NC probes allowed for the quantitative and sensitive detection of different mutant alleles. This rapid, easy and reliable diagnostic method is expected to allow the detection of myeloid malignancies. View Video
The ability to create functional biomolecules through bioconjugation has affected
every conceivable discipline in the life sciences. The application of available
cross-linking reactions and reagent systems for creating novel conjugates with peculiar
activities has made it possible for applications such as ligand discovery, disease
diagnosis, and high-throughput screening. These powerful methods owe their existence
to the discovery of chemoselective reactions that enable bioconjugation under physiological
conditions, a tremendous advancement for next generation drug development.
Bio-Synthesis, a leading biology CRO, focuses exclusively on early drug discovery
and development services. Relying on our state-of-the-art manufacturing facility
and over 30 years of combined experience in complex API conjugate technologies,
our bioconjugation-based drug discovery and development program, have delivered thousands
of hybrid complexes that are supported by our in-house bioanalytical laboratory
with a full spectrum of analytical tools capable of producing technically challenging
yet safe and efficacious drug conjugates. From project scope analysis and problem
solving proposals, to complex biopolymer production and assay development, we strive
with competence and confidence to meet your demand for creating novel conjugates
that can be quickly and cost-effectively added to your value chain.
For additional information, please contact us or send an email to email@example.com
We offer personalized solution for the conjugation of small molecules such as drugs,
metabolites, and labeled compounds with synthetic or natural polymers for specific
applications. Our conjugation services include:
At Bio-Synthesis, custom bioconjugation reagents are manufactured under a strict
quality control process to assure customers' complete satisfaction. Our sizeable
investment in state-of-the-art analytical equipment provides industry-leading tools
to develop and monitor our process. Complementary techniques, such as analytical
chromatography and electrophoresis, are routinely used to verify that specifications
are met. Sometimes, if the biopolymer is not too massive, mass spectroscopy can
be used to determine its molecular weight. However, unless a crystal structure is
available or a single unique functional group was used for conjugation, it may be
difficult to know the exact conjugation site and the molar ratio of the reactants.
Because of this complexity and difficulty, the effort required assessing the composition
and purity of a bioconjugate depends largely on the requirements and rigor of the
downstream research. At Bio-Synthesis, we strive with competence and confidence
to efficiently and affordably meet your demand for developing pre-clinical drug candidates or innovative regents
and tools. With our track record, Bio-Synthesis is your
ideal and reliable innovative partner in targeted drug discovery.
The application of available chemical reactions and reagent systems through bioconjugation
chemistry for creating novel complexes with unique activities has been used
in the area of: