Distinct roles for IP-10/CXC L10 in three animal models, Theiler’s virus infection, EA E, and MHV infection, for multiple sclerosis: implication of differing roles for IP-10
Ikuo Tsunoda; Thomas E Lane; Jana Blackett; and Robert S Fujinami
05/22/2014
Theiler’s murine encephalomyelitis virus (TMEV) causes demyelinatio n with inflammation of the central nervous system (CNS) in mice and is used as an animal model for multiple sclero sis (MS). Inter feron-g inducible pro tein-10 kDa (IP-10) is a CXC chemo kine and a chemo attractant for CXC R3» T cells. IP-10 mRNA is expressed in the CNS during TMEV infectio n. However, administratio n of anti-IP- 10 serum caused no difference in clinical signs, inflammation, demyelinatio n, virus persistence or anti-v irus antibo dy response in TMEV infectio n, while levels of virus specific and auto reactive lymphopro liferation increased. This likely reflects a difference in the pathogenesis of TMEV infection from that of two other animal models for MS, mouse hepatitis virus infectio n and exper imental allergic encephalomyelitis (EAE), where blocking of IP-10 resulted in clinical and histological improvement with suppression of antigen specific lymphopro liferation. In this review, we compare and contrast the roles of IP-10 between the three animal models for MS, and discuss the relevance to MS patients with different clinical courses.