Bio-Synthesis provides phosphonoacetate (PACE) DNA oligonucleotides that contain a phosphoacetate linkage in place of the standard phosphodiester linkage. Oligonucleotides containing this modification show great potential as biological modifiers in a wide variety of research applications. It offer improved transfection characteristics, enhanced nuclease resistance, and show considerable active in siRNA duplexes and accelerate the inital rate of cleavage by RNse H1 when incorporated with phosphorothioates, this modification also exhibit an enhancement in penetration of cultured cell .

Phosphonoacetate oligos are synthesized by Bio-Synthesis can be combined with other bases and/or sugar modified. These PACE oigo  can be specified to have fully phosphonoacetate linkage substituted or a mixture of diester and thioate linkages as specified. Contact us for phosphonoacetate DNA synthesis.

Product Information


Product Name:

Phosphonoacetate PACE DNA Oligonucleotide Modification


Backbone Modification, Antisense, Nuclease Resistance

Modification Code:



Bio-Synthesis Inc. Oligo Structure



Delivery Format:


Shipping Conditions:

Room Temperature

Storage Conditions:

-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.