Spacer 9 Oligonucleotide Modification

Spacer 9, spacer 18, Spacer C12, Spacer C3 can be inserted in multiple location within can oligonucleotide when a longer spacer is required. Spacer 9 is a triethylene glycol chain that is 9 atoms long (6 carbons + 3 oxygens). Spacer 9 has been used in various applications example such as using spacer 9 to form non-nucleotide bridges in hairpin loops in oligonucleotides Spacer 9 modified oligonucleotides can be used for epitope drug developmen. Other application such as solid-phase immobilization of hybridization probes. Multiple addition of Spacer 9 has been used to form long, flexible linker arms between the two domains of a bifunctional DNA oligonucleotide, in order to maximize the binding flexibility.

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Product Information

 

Product Name:

Spacer 9 Oligonucleotide Modification

Category:

spacer, linker, PEG linker, TEG

Modification Code:

[SP9]

Chemical Formula:

C6H13O6P

Exact Mass:

212.05

Formula Weight:

212.14

m/z:

212.04 (100.0%), 213.05 (6.9%), 214.05 (14%)

Elemental Analysis:

C, 33.97; H,6,18;O,45.25; P,14.60

Structure:

Purification:

HPLC or PAGE

Delivery Format:

Lyophilized

Shipping Conditions:

Room Temperature

Storage Conditions:

-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.

Related Products:

>Spacer Modified Oligonucleotide Synthesis

C12 Spacer, Spacer C12 Oligonucleotide Modification

C3 Spacer, Spacer C3 Oligonucleotide Modification

C6 Spacer, Spacer C6 Oligonucleotide Modification

Spacer 18 (Hexaethylene glycol) Oligonucleotide Modification

C9 Spacer, Spacer C9 Oligonucleotide Modification

References/Citations:

1. Nelson, J.S., Giver, L., Ellington, A.D., Letsinger, R.L. Incorporation of Non-Nucleotide Bridge into Hairpin Oligonucleotides Capable of High-Affinity Binding to the Rev Protein of HIV-1. Biochemistry. (1996), 35: 5339-5344.
2. Palma, E., Klapper, D.G., Cho, M.J. Antibodies as Drug Carriers III: Design of Oligonucleotides with Enhanced Binding Affinity for Immunoglobulin G. Pharm. Res. (2005), 22: 122-127.
3. Beattie, W.G., Meng, L., Turner, S.L., Varma, R.S., Dao, D.D., Beattie, K.L. Hybridization of DNA targets to glass-tethered oligonucleotide probes. Mol. Biotechnol. (1995), 4: 213-225.
4. Rogers, F.A., Vasquez, K.M., Egholm, M., Glazer, P.M. Site-directed recombination via bifunctional PNA-DNA conjugates. Proc. Natl. Acad. Sci. USA (2002), 99: 16695-16700. - Spacer 9

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