Literature Vault

It provides an exhaustive account of the advances made from the discovery of LNA to the latest developments in the area of LNA research. Beginning from synthetic methods and the different structural analogues of LNA synthesized until now, it gives detailed insight into the multiple novel attributes of LNA that make it preferable over all other classes of modified nucleic acid analogues for in ViVo applications. An explicit account of the succcessful application of LNA technology in different areas of research such as antisense and antigene strategies, diagnostics, genotyping, and so forth is described along with the current status of LNA in clinical trials. The review concludes with a discussion of the future prospects of LNA technology in the field of therapeutics and genomics.