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Peptides with Anti-Cancer Properties

Klaus D. Linse

A review of the scientific biomedical literature reveals that many peptides have anti-cancer activities or properties. The following table contains a list of peptides that are reported to have anti-cancer activities against solid and hematological tumors. Their oncolytic properties, or their ability to destroy tumor cells, are shown here as well. [Gaspar et al. 2013].
Peptides with Anti-Cancer Properties
Peptide
Amino acid sequence
Anticancer Activity
Cancer Cell
D-peptide A
D-peptide B
D-peptide C
D-peptide D
RLYLRIGRR
RLRLRIGRR
ALYLAIRRR
RLLLRIGRR
Cell membrane disruption
Human cervix, glioma, lung, mouse myeloma, African green monkey kidney
D-K6L9
LKLLKKLLKK LLKLL
Necrosis via membrane depolarization
Human prostate
NRC-03
GRRKRKWLRR IGKGVKIIGG AALDHL
Cell membrane lysis
Human breast
NRC-07
RWGKWFKKAT HVGKHVGKAA LTAYL
Cell membrane lysis
Human breast
Gomesin
ZCRRLCYKQR CVTYCRGR
Unclear
Murine melanoma, human breast, colon and cervix adenocarcinoma
Hepcidin TH2-3
QSHLSLCRWC CNCCRSNKGC
Cell membrane lysis
Human cervix, hepatocellular carcinoma, fibrosarcoma
Dermaseptin B2
GLWSKIKEVG KEAAKAAAK AAGKAALGAV SEAV
Necrosis
Human prostate and breast
PTP7
FLGALFKALS KLL
Apoptosis induction
Human lung, breast and hepatocellular carcinoma
MGA2
GIGKFLHSAK KFGKAFVGEI MNSGGKKWKM RRNQF–WVKVQRG
Necrosis and apoptosis
Cervix and lung, melanoma, rat glioma
HNP-1
ACYCRIPACI AGERRYGTCI YQGRLWAFCC
Mediation of antitumor immunity
Mouse colon and brest
Tachyplesin
KWCFRVCYRG ICYRRCR
Activation of the classic complement pathway
Human prostate
Temporin-1CEa
FVDLKKIANI INSIF
Membrane disruption, calcium release, ROS production
Human breast
NK-2
KILRGVCKKI MRTFLRRISK DILTGKK
Necrotic death after peptide intercalation into phospholipid phosphatidylserine -containing membranes.
Human chronic myelogenous leukemia, histiocytic lymphoma, acute T cell leukemia, acute lymphoblastic leukemia, neuroblastoma, colorectal adenocarcinoma
Bovine lactoferricin B6 (LbcinB6)
RRWQWR
Apoptosis, disruption of mitochondrial membrane
Human acute lymphoblastic T leukemia, acute T cell leukemia
Cecropin CB1
KWKVFKKIEK MGRNIRNGIV KAGPKWKVFK KIEK
Unclear
Human acute lymphoblastic T leukemia, lung carcinoma, stomach carcinoma
 
 
Reference
 
Diana Gaspar, A. Salomé Veiga and Miguel A. R. B. Castanho; From antimicrobial to anticancer peptides. A review. Front. Microbiol., 01 October 2013 | doi: 10.3389/fmicb.2013.00294.