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LNA Bibliography

Arzumanov, A., Walsh, A.P., Rajwanshi, V.K., Kumar, R., Wengel, J., Gait, M.J. Inhibition of HIV-1 Tat-Dependent Trans Activation by Steric Block Chimeric 2''''-O-Methyl/LNA Oligoribonucleotides. Biochemistry 40(48):14645-14654, 2001.
Babu, B.R., and Wengel, J. Universal hybridization using LNA (locked nucleic acid) containing a novel pyrene LNA nucleotide monomer. Chem. Commun. 20:2114-2115, 2001.
Babu, B.R., Prasad, A.K., Trikha, S., Thorup, N., Parmar, V.S., Wengel, J. Conformationally locked aryl C-nucleosides: synthesis of phosphoramidite monomers and incorporation into single-stranded DNA and LNA. J. Chem. Soc., Perkin Tran. 1 22:2509-2519, 2002.
Bondensgaard, K., Peterson, M., Singh, S.K., Rajwanshi, V.K., Kumar, R., Wengel, J., Jacobsen, J.P. Structural studies of LNA:RNA duplexes by NMR: conformations and implications for RNase H activity. Chemistry 6(15):2687-95, 2000.
Braasch, D.A. and Corey, D.R. Locked Nucleic Acid (LNA): fine-tuning the recognition of DNA and RNA. Chemistry & Biology 55:1-7, 2000. Braasch, D.A., and Corey, D.R. Novel Antisense and Peptide Nucleic Acid Strategies for Controlling Gene Expression. Biochemistry 41(14), 2002.
Braasch, D.A., Liu, Y., and Corey, D.R. Antisense inhibition of gene expression in cells by oligonucleotides incorporating locked nucleic acids: effect of mRNA target sequence and chimera design. Nucleic Acids Research 30(23):5160-5167, 2002
Christensen, N.K., Petersen, M., Nielsen, P., Jacobsen, J.P., Olsen, C.E. and Wengel, J. A novel class of oligonucleotide analogues containing 2''-0,3''-C-linked [3.2.0] bicycloarabinonucleoside monomers: synthesis, thermal affinity studies, and molecular modeling. J. Am. Chem. Soc. 120:5458-5463, 1998.
Christensen, N.K., Dahl, B.M., and Nielsen, P. Incorporation of á– and â–LNA (Locked nucleic acid) monomers in oligodeoxynucleotides with polarity reversals. Bioorg.&Medic.Chem.Letters 11(13):1765-1768, 2001.
Christensen, N.K., Dalskov, J.K., and Nielsen, P. Synthesis and evaluation of á-LNA. Nucleosides, Nucleot. & Nucleic Acids 20:825-828, 2001.
Christensen. U., Jacobsen, N., Rajwanshi, V.K., Wengel, J. and Koch, T. Stopped-flow kinetics of locked nucleic acid (LNA)-oligonucleotide duplex formation: studies of LNA/DNA and DNA/DNA interactions. Biochem J. 354:481-484, 2001.
Crinelli, R., Bianchi, M., Gentilini, L. and Magnani, M. Design and characterization of decoy oligonucleotides containing locked nucleic acids. Nucleic Acids Research 30(11):2435-2443, 2002.
Crinelli, R., Bianchi, M., Gentilini, L., Palma, L., Sørensen, M.D., Bryld, T., Babu, R.B., Arar, K., Wengel, J., and Magnani, M. Transcription factor decoy oligonucleotides modified with locked nucleic acids: an in vitro study to reconcile biostability with binding affinity. Nucleic Acids Research 32(6):1874-1885, 2004.
Di Giusto, D.A., and King, G.C. Strong positional preference in the interaction of LNA oligonucleotides with DNA polymerase and proofreading exonuclease activities: implications for genotyping assays. Nucleic Acids Research Vol. 32, No. 3 e32, 2004.
Dominick, P.K., and Jarstfer, M.B. A Conformationally Constrained Nucleotide Analogue Controls the Folding Topology of a DNA G-Quadruplex. Submitted for Publication: J. Am. Chem. Soc., 2003.
Egli, M., Minasov, G., Teplova, M., Kumar, R., and Wengel, J. X-ray crystal structure of a locked nucleic acid (LNA) duplex composed of a palindromic 10-mer DNA strand containing one LNA thymine monomer. Chem. Commun. 651-652, 2001.
Elayadi, A.N., Braasch, D.A. and Corey, D.R. Implications of High-Affinity Hybridization by Locked Nucleic Acid Oligomers for Inhibition of Human Telomerase. J. Am. Chem. Soc. Submitted for publication, 2002.
Fahmy, R.G., and Khachigian, L.M. Locked nucleic acid modified DNA enzymes targeting early growth response-1 inhibit human vascular smooth muscle cell growth. Nucleic Acids Research 32(7):2281-2285, 2004.
Fluiter, K., ten Asbroek, L.M.A., de Wissel, M.B., Jakobs, M.E., Wissenbach, M., Olsson, H., Olsen, O., Oerum, H., and Baas, F. In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides. Nucleic Acids Research 31(3):953-962, 2003.
Grünweller, A., Wyszko, E., Bieber, B., Jahnel, R., Erdmann, V.A., and Kurreck, J. Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2''-O-methyl RNA, phosphorothioates and small interfering RNA. Nucleic Acids Research 31(12):3185-3193, 2003.
Håkansson, A. E., Koshkin, A.A., Srensen, M.D. and Wengel J. Convenient syntheses of 7-Hydroxy-1-(hydroxymethyl)-3-thymin-1-yl)-2, 5-dioxabicyclo [2.2.1] heptanes: alpha-L-Ribo-and alpha-L-xylo-configured LNA Nucleosides. J. Org. Chem. 65(17):5161-5166, 2000.
Håkansson, A.E., and Wengel, J. The adenine derivative of á–L-LNA (á-L-ribo configured locked nucleic acid): synthesis and high-affinity hybridization towards DNA, RNA, LNA and á–L-LNA complementary sequences. Bioorganic & Medic. Chem. Letters 11(7):935-938, 2001.
Hertoghs, K.M.L., Ellis, J.H., and Catchpole, I.R. Use of locked nucleic acid oligonucleotides to add functionality to plasmid DNA. Nucleic Acids Research 31(20):5817-5830, 2003.
Jacobsen, N., Bentzen, J., Meldgaard, M., Jakobsen, M.H., Fenger , M.., Kauppinen, S., Skouv, J. LNA-enhanced detection of single nucleotide polymorphisms in the apolipoprotein E. Nucleic Acids Research Vol. 30 No. 19 e100, 2002.
Jacobsen, N., Stein Nielsen, P., Charlton Jeffares, D., Eriksen, J., Ohlsson, H., Arctander, P., and Kauppinen, S. Direct isolation of poly(A)+ RNA from 4 M guanidine thiocyanate-lysed cell extracts using locked nucleic acid-oligo(T) capture. Nucleic Acids Research Vol. 32, No. 7 e64, 2004.
Jensen, G. A., Singh, S. K., Kumar, R., Wengel, J., and Jacobsen, J. P. A comparison of the solution structures of an LNA:DNA duplex and the unmodified DNA:DNA duplex. J. Chem. Soc., Perkin Trans. 2:1224-1232, 2001.
Johnson, M.P., Haupt, L.M., and Griffiths, L.R. Locked nucleic acid (LNA) single nucleotide polymorphism (SNP) genotype analysis and validation using real-time PCR. Nucleic Acids Research Vol. 32, No. 6 e55, 2004.
Koshkin, A.A. and Wengel, J. Synthesis of Novel 2'', 3''-linked bicyclic thymine ribonucleosides. J. Org. Chem. 63:2778-2781, 1998.
Koshkin, A.A., Nielsen, P., Meldgaard, M., Rajwanshi, V.K., Singh, S.K. and Wengel, J. LNA (locked nucleic acid): an RNA mimic forming exceedingly stable LNA:LNA duplexes. J. Am. Chem. Soc. 120:13252-13253, 1998.
Koshkin, A.A., Rajwanshi, V.K. and Wengel, J. Novel convenient syntheses of LNA [2.2.1] bicyclo nucleosides. Tetrahedron Lett. 39:4381-4384, 1998.
Koshkin, A.A., Singh, S.K., Nielsen, P., Rajwanshi, V.K., Kumar, R., Meldgaard, M., Olsen, C.E. and Wengel, J. LNA (locked nucleic acids): synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition. Tetrahedron 54:3607-3630, 1998.
Kumar, R., Singh, S.K., Koshkin, A.A., Rajwanshi, V.K., Meldgaard, M. and Wengel, J. The first analogues of LNA (locked nucleic acids): phosphorothioate-LNA and 2''-thio-LNA. Bioorg. Med. Chem. Lett. 8:2219-2222, 1998.
Kurreck, J., Wyszko, E., Gillen, C., Erdmann, V.A. Design of antisense oligonucleotides stabilized by locked nucleic acids. Nucleic Acids Research 30(9):1911-1918, 2002.
Kværnø, L. and Wengel, J. Investigation of restricted backbone conformations as an explanation for the exceptional thermal stabilities of duplexes involving LNA (locked nucleic acids): synthesis and evaluation of abasic LNA. Chem. Commun. 657-658, 1999.
Kværnø, L., Kumar, R., Dahl, B.M., Olsen, C.E. and Wengel J. Synthesis of abasic locked nucleic acid and two seco-LNA derivatives and evaluation of their hybridization properties compared with their more flexible DNA counterparts. J. Org. Chem. 65 (17):5167-76, 2000.
Kværnø, L., Wightman, R.H., and Wengel, J. Synthesis of a Novel Bicyclic Nucleoside Restricted to an S-Type Conformation and Initial Evaluation of Its Hybridization Properties When Incorporated into Oligodeoxynucleotides. J. Org. Chem. 66(15):5106-5112, 2001.
Latorra, D., Campbell, K., Wolter, A., and Hurley, J.M. Enhanced Allele-Specific PCR Discrimination in SNP Genotyping Using 3’ Locked Nucleic Acid (LNA) Primers. Human Mutation 22:79-85, 2003.
Latorra, D., Arar, K., and Hurley, J.M. Design considerations and effects of LNA in PCR primers. Molecular and Cellular Probes 17:253-259, 2003.
Lauritsen, A., Wengel, J. Oligodeoxynucleotides containing amide-linked LNA-type dinucleotides: synthesis and high-affinity nucleic acid hybridization. Chem. Commun. 5:530-531, 2002.
Letertre, C., Perelle, S., Dilasser, F., Arar, K., and Fach, P. Evaluation of the performance of LNA and MGB probes in 5’-nuclease PCR assays. Molecular and Cellular Probes 17:307-311, 2003.
McTigue, P., Peterson, R.J., and Kahn, J.D. Sequence-Dependent Thermodynamic Parameters for Locked Nucleic Acid (LNA)-DNA Duplex Formation. Submitted for Publication: Biochemistry, 2004.
Nielsen, C.B., Singh, S.K., Wengel, J. and Jacobsen, J.P. The solution structure of a locked nucleic acid (LNA) hybridized to DNA. J. Biomol. Struc. & Dyn. 17:175-191, 1999.
Nielsen, K.E., Singh, S.K., Wengel, J. and Jacobsen, J.P. Solution structure of an LNA hybridized to DNA: NMR study of the d(CTLGCTLTLCTLGC):d(GCAGAAGCAG) duplex containing four locked nucleotides. Bioconjugate Chem. 11:228-238, 2000. Nielsen, P., Pfundheller, H.M., Olsen, C.E. and Wengel, J. Synthesis of 2''-0,3''-C-linked bicyclic nucleosides and bicyclic oligonucleotides. J. Chem. Soc., Perkin Trans. 1:3423-3433, 1997.
Nielsen, P., Pfundheller, H.M. and Wengel, J. A novel class of conformationally restricted oligonucleotide analogues: synthesis of 2'',3''-bridged monomers and RNA-selective hybridisation. Chem. Commun. 825-826, 1997.
Nielsen, P. and Wengel, J. Synthesis and chemoselective activation of phenyl 3,5-di-O-benzyl-2-O,4-C-methylene-1-thio--D-ribofuranoside: a key synthon towards -LNA. Chem. Commun. 2645-2646, 1998.
Nielsen, P. and Wengel, J. A new synthetic approach towards - and - LNA (locked nucleic acids). Nucleosides & Nucleotides 18:701-702, 1999.
Nielsen, P., Christensen, N.K., and Dalskov, J.K. á –LNA (Locked Nucleic Acid with á–D-Configuration): Synthesis and Selective Parallel Recognition of RNA. Chemistry 8(3):712-722, 2002.
Nielsen-Ellemann, K.M., Petersen, M., Hakansson, A.E., Wengel, J., and Jacobsen, J.P. á-L-LNA (á-L-ribo configured locked nucleic acid) recognition of DNA: an NMR spectroscopic study. Chemistry 8:3001-3009, 2002.
Obika, S., Nanbu, D., Hari, Y., Andoh, J., Morio, K., Doi, T., Imanishi, T. Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2''-O,4''-C-methylene ribonucleosides. Tetrahedron Lett. 39:5401-5404, 1998.
Ørum, H., Jakobsen, M.H., Koch, T., Vuust, J. and Borre, M.B. Detection of the Factor V Leiden mutation by direct allele-specific hybridization of PCR amplicons to photoimmobilized locked nucleic acids. Clin. Chem. 45:1898-1905, 1999.
Ørum, H. and Wengel, J. Locked nucleic acids: a promising molecular family for gene-function analysis and antisense drug development. Curr. Opinion in Mol. Therap. 3(3):239-243, 2001.
Parekh-Olmedo, H., Drury, M., and Kmiec, E.B. Targeted Nucleotide Exchange in Saccharomyces cerevisiae Directed by Short Oligonucleotides Containing Locked Nucleic Acids. Chemistry & Biology 9:1073-1084, 2002.
Petersen, M., Håkansson, A. E., Wengel, J., and Jacobsen, J. P. alpha –L-LNA (alpha- I-ribo configured locked nucleic acid) recognition of RNA. A study by NMR spectroscopy and molecular dynamics simulations. J. Am. Chem. Soc. 123(30):7431-7432, 2001.
Petersen, M., Nielsen, C.B., Nielsen, K.E., Jensen, G.A., Bondensgaard, K., Singh, S.K., Rajwanshi, V.K., Koshkin, A.A., Dahl, B.M., Wengel, J. and Jacobsen, J.P. The conformations of locked nucleic acids (LNA). J. Mol. Recognit. 13:44-53, 2000.
Petersen, M., Bondensgaard, K., Wengel, J., and Jacobsen, J.P. Locked Nucleic Acid (LNA) Recognition of RNA: NMR Solution Structures of LNA:RNA Hybrids. J. Am. Chem. Soc. 124:5974-5982, 2002.
Pfundheller, H.M., Koshkin, A.A., Olsen, C.E. and Wengel, J. Evaluation of oligonucleotides containing two novel 2''-0-methyl modified nucleotide monomers: a 3''-C-allyl and 2''-0-3''-C-linked bicyclic derivative. Nucleosides & Nucleotides 18:2017-2030, 1999.
Rajwanshi, V.K., Håkansson, A.E., Dahl, B.M. and Wengel, J. LNA stereoisomers: xylo-LNA (-D-xylo configured locked nucleic acid) and -L-LNA (-L-ribo configured locked nucleic acid). Chem. Commun. 1395-1396, 1999.
Rajwanshi, V.K., Håkansson, A.E., Kumar, R. and Wengel, J. High-affinity nucleic acid recognition using ''LNA'' (locked nucleic acid, -D-ribo configured LNA), ''xylo-LNA'' (-D-xylo configured LNA) or ''-L-LNA'' (-L-ribo configured LNA). Chem. Commun. 2073-2074, 1999.
Rajwanshi, V.K., Kumar, R., Kofod-Hansen, M. and Wengel, J. Synthesis and restricted furanose conformations of three novel bicyclic thymine nucleosides: a xylo-LNA nucleoside, a 3''-O,5''-C-methylene-linked nucleoside, and a 2''-O,5''-C-methylene linked nucleoside. J. Chem. Soc. Perkin Trans. 1:1407-1414, 1999.
Raunkjær, M., Olsen, C.E. and Wengel, J. Oligonucleotide analogues containing (2"S)- and (2"R)-2''-0,3''-C-((2"-C-hydroxymethyl)ethylene)-linked bicyclic nucleoside monomers: Synthesis, RNA-selective binding, and diastereoselective formation of a very stable homocomplex based on T:T base pairing. J. Chem. Soc. Perkin Trans. 1:2543-2551, 1999.
Silahtaroglu, A.N., Tommerup, N., and Vissing, H. FISHing with locked nucleic acids (LNA): evaluation of different LNA/DNA mixmers. Molecular and Cellular Probes 17(4):165-169, 2003.
Simeonov, A. and Nikiforov, T.T. Single nucleotide polymorphism genotyping using short, fluorescently labeled locked nucleic acid (LNA) probes and fluorescence polarization detection. Nucleic Acids Research Vol. 30 No. 17 e91, 2002.
Singh, S.K. and Wengel, J. Universality of LNA-mediated-high-affinity nucleic acid recognition. Chem. Commun. 1247-1248, 1998.
Singh, S.K., Kumar, R. and Wengel, J. Synthesis of 2''-amino-LNA: a novel conformationally restricted high-affinity oligonucleotide analogue with a handle. J. Org. Chem. 63:10035-10039, 1998.
Singh, S.K., Kumar, R. and Wengel, J. Synthesis of novel bicyclo [2.2.1] ribonucleosides: 2''-amino- and 2''-thio-LNA monomeric nucleosides. J. Org. Chem. 63:6078-6079, 1998.
Singh, S.K., Nielsen, P., Koshkin, A.A. and Wengel, J. LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition. Chem. Commun. 455-456, 1998.
Sørensen, M.D., Meldgaard, M., Rajwanshi, V.K., Wengel, J. Branched oligonucleotides containing bicyclic nucleotides as branching points and DNA or LNA as triplex forming branch. Bioorg. Med. Chem. Lett. 10(16):1853-6, 2000.
Sørensen, M.D., Kværnø, L., Bryld, T., Håkansson, A.E., Verbeure, B., Gaubert, G., Herdewijn, P., and Wengel, J. á-L-ribo-Configured Locked Nucleic Acid (á-L-LNA): Synthesis and Proberties. J. Am. Chem. Soc. 124(10):2164-2176, 2002.
Tolstrup, N., Nielsen, P.S., Kolberg, J.G., Frankel, A.M., Vissing, H., and Kauppinen, S. OligoDesign: optimal design for LNA (locked nucleic acid) oligonucleotide capture probes for gene expression profiling. Nucleic Acids Research 31(13):3758-3762.
Torigoe, H., Hari, Y., Sekiguchi, M., Obika, S. and Imanishi, T. 2''-O, 4''-C methylene bridged nucleic acid (2'', 4''-BNA) modification promotes pyrimidine motif triplex DNA formation at physiological pH: thermodynamic and kinetic studies. J. Biol. Chem. 276:2354-2360, 2001.
Ugozzoli, L.A., Latorra, D., Pucket, R., Arar, K., and Hamby, K. Real-time genotyping with oligonucleotide probes containing locked nucleic acids. Analytical Biochemistry 324:143-152, 2004.
Vester, B., Lundberg, L.B., Sørensen, M.D., Babu, B.R., Douthwaite, S., and Wengel, J. LNAzymes: Incorporation of LNA-Type Monomers into DNAzymes Markedly Increases RNA Cleavage. J. Am. Chem. Soc. 124:13682-13683, 2002.
Wahlestedt, C., Salmi, P., Good, L., Kela, J., Johnsson, T., Hökfelt, T., Broberger, C., Porreca, F., Lai, J., Ren, K., Ossipov, M., Koshkin, A., Jakobsen, N., Skouv, J., Ørum, H., Jacobsen, M.H. and Wengel, J. Potent and nontoxic antisense oligonucleotides containing locked nucleic acids. Proc. Natl. Acad. Sci. U.S.A. 97(10):5633-5638, 2000. Wengel, J. Synthesis of 3''-C- and 4''-C-branched oligodeoxynucleotides and the development of LNA (locked nucleic acid). Acc. Chem. Res. 32:301-310, 1999.
Wengel, J., Koshkin A., Singh, S.K., Nielsen, P., Meldgaard, M., Rajwanshi, V.K., Kumar, R., Skouv, J., Nielsen, C.B., Jacobsen, J.P., Jacobsen, N. and Olsen, C.E. LNA (locked nucleic acid). Nucleosides & Nucleotides 18:1365-1370, 1999.
Wengel, J. LNA (locked nucleic acid). Antisense Drug Technology 339-357, 2001.
Wengel, J., Petersen, M., Nielsen, K.E., Jensen, G.A., Håkansson, A.E., Kumar, R., Sørensen, M.D., Rajwanshi, V.K., Bryld, T., and Jacobsen, J.P. LNA (locked nucleic acid) and the diastereoisomeric á–L-LNA: conformational tuning and high-affinity recognition of DNA/RNA targets. Nucleosides, Nucleotides & Nucleic Acids 20:389-396, 2001.