When it comes to your product, choosing the right partner is one of the biggest decisions you'll make. Don't just take our word for it—see what one of our clients had to say about their experience working with us.

We’re excited to be exhibiting at the 22nd Annual Meeting of the Oligonucleotide Therapeutics Society! This event brings together the brightest minds in oligonucleotide research and therapeutic innovation, and we’re looking forward to connecting with scientists, industry leaders, and collaborators from around the world. Stop by our booth to discover how our solutions are helping accelerate breakthroughs in nucleic acid therapeutics, exchange ideas with our team, and explore new opportunities to advance the future of precision medicine. We can't wait to see you there!

Check out our Cyclotides and Macrocylic Peptides as Therapeutics Poster
Check out our Guanidinium Morpholinos (GMOs) as Therapeutics Poster

Seeing the memories from last year’s TIDES: Oligonucleotides and Peptide Therapeutics and the wonderful moments we shared truly gets us excited! We’re thrilled to announce that we’ll be attending Tides 2026. We can’t wait to reconnect with familiar faces and meet new friends. Here’s to another incredible event full of connection, inspiration, and fun. Don’t forget to stop by booth 707—we’d love to see you there!
See recap

We’re excited to share our latest commitment! We’ve recently started the process to obtain ISO 14001, reinforcing our dedication to environmental sustainability. Stay tuned for more updates as we continue to raise the bar! 🌎 💚
#ISO9001 #ISO13485 #ISO14001 #Sustainability

With just a few days left, we’re excited to be part of the Oligonucleotide Therapeutics Society (OTS)! We look forward to connecting with fellow innovators and exploring new opportunities in oligonucleotide research and development.

Stop by booth #32 to see how Bio-Synthesis can empower your next oligo project with our custom synthesis solutions and expertise. Let’s work together to push the boundaries of oligonucleotide therapeutics!
#OTS #oligotherapeutics #oligonucleotidetherapeutics #BioSynthesis #BSI

🔬 Elevate your research with Bio-Synthesis’s premium maleimide-functionalized oligos! 🧬

Unlock new possibilities in your projects with our expertly crafted oligo solutions, designed to offer unparalleled precision and flexibility for your bioconjugation needs. Whether you're working on targeted therapeutics, advanced biosensors, or innovative probes, our high-quality maleimide oligos ensure seamless and efficient conjugation every time.

Trust Bio-Synthesis to provide you with the perfect tools for your cutting-edge projects. Reach out today and experience the difference in your scientific breakthroughs!

Learn more

#Research #Bioconjugation #OligoSolutions #BioSynthesis #BSI

TIDES 2025 was a truly inspiring gathering, bringing together some of the most innovative minds in the scientific community. The opportunity to engage with brilliant researchers, exchange ideas, and explore groundbreaking advancements made every interaction deeply meaningful.

Each conversation was a moment of insight—an exploration of new perspectives, cutting-edge discoveries, and shared aspirations for the future of science.

As we reflect on the wealth of knowledge gained, we are eager to apply these insights in meaningful ways. We are immensely grateful for the connections made and look forward to keeping the conversations going as we work toward shaping the future of the field together.

#TidesUSA #TIDESUSA #BioSynthesis #BSI #Oligos #Peptide #BioSynthesisI

    

Exiting news📢‼️
Bio-Synthesis Inc. is excited to share we will be attending TIDES USA 2025, happening from May 19-22. Be sure to visit us at booth 817 for the opportunity to chat with one of our scientists. We hope to see you there and look forward to all the wonderful connections soon to be made. #TIDESUSA #BioSynthesis #BSI #Oligos #Peptide #BioSynthesisInc #Oligonucleitides

Unlocking the potential of RNA interference has revolutionized gene expression studies in cell cultures. RNAi technology has enabled precise gene silencing, offering insights into cellular processes, and opening new avenues for therapeutic development. With this technology, researchers can better understand how genes function and how they contribute to diseases, allowing for the development of more effective treatments. #RNAi hashtag#GeneSilencing hashtag#BiotechInnovation

Click Here to Discover More!

Bio-Synthesis Inc. cordially invites you to join us for an exciting and informative experience at Booth 515 for refreshments, expert consultation, and exclusive merchandise. Don’t miss this opportunity to network with industry leaders and discover how Bio-Synthesis Inc. can support your innovative projects. Visit Booth 515 today – we look forward to meeting you!

Exciting news! 📣 Bio-Synthesis Inc. is thrilled to announce that we will be showcasing our latest innovations at Tides USA 2024 from May 14-17. Discover new services and solutions at booth 515, and don't miss the poster presentation by Kavitha Sudheendran. Meet our experts and explore what's shaping the future of biotech innovations! #BioSynthesis #TidesUSA2024 #Biotech #Innovations #Booth515

Bio-Synthesis had a great time at the 9th Annual OTP Congress! Our new facility was showcased, and we had the opportunity to sit down with Dr. Marvin Caruthers. We were thrilled to speak with many attendees about how our oligonucleotide technology can advance their research. A big thank you to Miguel Castro, Heidi Fazeli, and Rebecca Yen for representing our team at the event! hashtag#BioSynthesis hashtag#OTPCongress hashtag#oligonucleotide hashtag#technology

Please check out this informative article review by Our Senior Scientist, Kavitha Sudheendran! You can find more engaging news, updates, and articles at our Technical and Educational Questions base on Biosyn.com.

Diagnosis and prediction of oral cancer using saliva-based microRNA.

Oral cancer is the sixteenth most common cancer, accounting for approximately three percent of all cancers diagnosed annually in the United States. In 2022, there were about 54,000 new cases reported. Despite the high number of cases, there is not much research conducted on the early detection of oral cancer. However, a recent article by Punyadeera et al. has proposed an exciting method for the early diagnosis and prediction of oral cancer risk in oral potentially malignant disorders (OPMD).

Click here for more information!

 We are proud to announce that, thanks to the continued support of our customers and our commitment to exceeding their expectations, we have successfully expanded our operations by relocating from a 10,000-square-foot facility to a state-of-the-art 52,000-square-foot facility.

We completed our move in June 2023 and have continued to grow ever since. This expansion allows us to offer more space, advanced instrumentation, and an exceptional team of professionals dedicated to supporting your projects. With enhanced capabilities, greater precision, uncompromising quality, and faster turnaround times, we are better equipped than ever to meet your needs and deliver outstanding results.

A heartfelt thank you to all our customers and staff whose trust, dedication, and support have helped Bio-Synthesis Inc. continue to grow. Your partnership and commitment have been instrumental in our success, and we look forward to achieving even greater milestones together.

Shivarov et al. published their work using BNA-NC probes allowed for the quantitative and sensitive detection of different mutant alleles. This rapid, easy and reliable diagnostic method is expected to allow the detection of myeloid malignancies. View Video

Complete our BNA3 online survey and receive a free BNA T-shirt now

Like Curry? New Biological Role Identified For Compound Used In Ancient Medicine

Friday, May 25, 2012

Source : Oregon State University

CORVALLIS, Ore. – Scientists have just identified a new reason why some curry dishes, made with spices humans have used for thousands of years, might be good for you.

New research at Oregon State University has discovered that curcumin, a compound found in the cooking spice turmeric, can cause a modest but measurable increase in levels of a protein that's known to be important in the "innate" immune system, helping to prevent infection in humans and other animals.

This cathelicidin antimicrobial peptide, or CAMP, is part of what helps our immune system fight off various bacteria, viruses or fungi even though they hadn't been encountered before.

Prior to this, it was known that CAMP levels were increased by vitamin D. Discovery of an alternative mechanism to influence or raise CAMP levels is of scientific interest and could open new research avenues in nutrition and pharmacology, scientists said.

Turmeric is a flavorful, orange-yellow spice and an important ingredient in many curries, commonly found in Indian, South Asian and Middle Eastern cuisine. It has also been used for 2,500 years as a medicinal compound in the Ayurvedic system of medicine in India – not to mention being part of some religious and wedding ceremonies. In India, turmeric is treated with reverence.

The newest findings were made by researchers in the Linus Pauling Institute at OSU and published today in the Journal of Nutritional Biochemistry, in collaboration with scientists from the University of Copenhagen in Denmark. The work was supported by the National Institutes of Health.

"This research points to a new avenue for regulating CAMP gene expression," said Adrian Gombart, an associate professor of biochemistry and biophysics in the Linus Pauling Institute. "It's interesting and somewhat surprising that curcumin can do that, and could provide another tool to develop medical therapies."

The impact of curcumin in this role is not nearly as potent as that of vitamin D, Gombart said, but could nonetheless have physiologic value. Curcumin has also been studied for its anti-inflammatory and antioxidant properties.

"Curcumin, as part of turmeric, is generally consumed in the diet at fairly low levels," Gombart said. "However, it's possible that sustained consumption over time may be healthy and help protect against infection, especially in the stomach and intestinal tract."

In this study, Chunxiao Guo, a graduate student, and Gombart looked at the potential of both curcumin and omega-3 fatty acids to increase expression of the CAMP gene. They found no particular value with the omega-3 fatty acids for this purpose, but curcumin did have a clear effect. It caused levels of CAMP to almost triple.

There has been intense scientific interest in the vitamin D receptor in recent years because of potential therapeutic benefits in treating infection, cancer, psoriasis and other diseases, the researchers noted in their report. An alternative way to elicit a related biological response could be significant and merits additional research, they said.

The CAMP peptide is the only known antimicrobial peptide of its type in humans, researchers said. It appears to have the ability to kill a broad range of bacteria, including those that cause tuberculosis and protect against the development of sepsis.

Bio-Synthesis is pleased to announce a new human cell line authentication service (called "tissue authentication" or "tissue validation" in oncology) for laboratories working with HLA, cancer cell and other cell lines.

Cell line contamination has interfered with scientific studies for years, but only recently has it come to the community's attention. In 2007, the NCI/ADR-RES breast cancer cell line was found to be contaminated with OVCAR-8, sparking the retraction of over 300 academic papers and compromising years of work.¹ Only months later, the NIH called for all grant applicants to address the threat of cross-contamination with cell line identification measures.² Increasing numbers of journals, notably Biotechniques, Cancer Research, and In Vitro Cellular and Developmental Biology now require authentication on all cell lines used in studies submitted for publication. The FDA is even more strict, requiring cell line authentication as a condition for drug approval.³

Over the years, several different teams of researchers have noted the failure of phenotype and provenance to provide reliable information:

• Of 1211 cell lines published between 1989 and 2007, 23 percent were found to have discrepancies in p53 status (Berglind et al).⁴
• Of 40 ostensibly thyroid cancer cell lines, 17 were found to lack unique genetic profiles, and some were confirmed as having come from colon cancer or melanoma sources (Schwepp et al).⁵
• Among hematopoietic cell lines, 14.8 percent were found to be contaminated with other hematopoietic cell lines (Drexler et al).⁶

Bio-Synthesis employs short tandem repeat analysis, the technique most highly recommended by the ATCC SDO, to confirm the identities of clients' submitted samples. Standard cell line authentication services start as low as $95 for a profile of preextracted DNA. Complete cell line identification packages, however, include not only AmpFℓSTR Identifiler profiling but PowerPlex 1.2, StemElite, and High-Resolution Luminex HLA DNA Genotyping. In-depth services include comparison of the client's cell line to a known sample, blind analysis of the client's cell line without any preexisting knowledge of its purported origin, comparison of the client's sample to a DNA database and and cross-contamination detection covering nine species.

Bio-Synthesis' accredited cell line testing facilities have been the home of many successful projects. Bio-Synthesis invites readers to visit www.BioSyn.com for more details on this and other services.

For further information, please contact:
Heidi Fazeli, [Sales Director]
Bio-Synthesis Incorporated
(800) 227-0627

1. Diamond, P.F. (Jan. 21, 2010). Cancer Cell Line Identity Crisis. Genetic Engineering and Biotechnology News. [Electronic 9-22-2010]
2. National Institutes of Health. Notice regarding authentication of cell lines. Retrieved 9-22-2010.
3. Wanjek, Christopher. The problem, policy, history and fix: Cleaning Up Cell-Line Cross-Contamination. The NIH Catalyst. March-April 2008. Web. September 29, 2010.
4. Barrallon, R.; Bauer, S.R.; Butler, J.; Capes-Davis, A.; Dirks, W.G.; Elmore, E.; Furtado, M.; Kline, M.C.; Kohara, A.; Los, G.V.; MacLeod, R.A.F.; Masters, J.R.W.; Nardone, M.; Nardone, R.M.; Nims, R.W.; Price, P.J.; Reid, Y.A.; Shewale, J.; Sykes, G.; Steuer, A.F.; Storts, D.R.; Thomson, J.; Taraporewala, Z.; Alston-Roberts, C.; Kerrigan, L. (Jul. 8, 2010). Recommendation of short tandem repeat profiling for authenticating human cell lines, stem cells, and tissues. In Vitro Cellular and Developmental Biology - Animal. [Electronic 9-22-2010]
5. Barrallon, R.; Bauer, S.R.; Butler, J.; Capes-Davis, A.; Dirks, W.G.; Elmore, E.; Furtado, M.; Kline, M.C.; Kohara, A.; Los, G.V.; MacLeod, R.A.F.; Masters, J.R.W.; Nardone, M.; Nardone, R.M.; Nims, R.W.; Price, P.J.; Reid, Y.A.; Shewale, J.; Sykes, G.; Steuer, A.F.; Storts, D.R.; Thomson, J.; Taraporewala, Z.; Alston-Roberts, C.; Kerrigan, L. (Jul. 8, 2010). Recommendation of short tandem repeat profiling for authenticating human cell lines, stem cells, and tissues. In Vitro Cellular and Developmental Biology - Animal. [Electronic 9-22-2010]
6. Drexler, H.G, Dirks, W.G., MacLeod, R.A.F. (Oct. 1999). False human hematopoietic cell lines: cross-contaminations and misinterpretations. Leukemia, 13(10), p. 1601-1607.

RNA purification is of critical importance in the preparation of samples for use in several applications including cDNA library construction, gene expression assay, in vitro translation, microarrays, Northern blot analysis, nuclease protection assays, real-time quantitative PCR, reverse transcription PCR, RNA mapping etc. Low quality RNA may strongly compromise the experimental results of these applications which are often labor-intensive, time-consuming, and highly expensive.

Bio-Synthesis Inc. has launched the RNATotal^TM Purification kit which can alleviate all challenges faced by researchers in obtaining quality RNA purification at unbelievably low price.

www.pr.com/press-release/40593

Contact our technical staff and we will be glad to assist you with the design, synthesis and bioconjugation of these Trojan Peptides to your specific molecule