Does Bio-Synthesis provide S-palmitoylated or S-acylation peptide synthesis?
Bio-Synthesis offers many type of posttranslational peptide modifications. Palmitoylation peptide can be modified at N-termnal or cystein side chain. is one of posttranslational peptide modification we offer. These Synthetic peptides have frequently been used to immunize animals. However, peptides less than about 20 to 30 amino acids long are poor immunogens. In general, to increase its immunogenicity, the presentation of the peptide should be improved, and molecular weight needs to be increased. Many attempts have been made to couple peptide immunogens to different carrier proteins [e.g. keyhole limpet haemocyanin (KLH) or ovalbumin]. This leads to very complex structures, however. We used a controlled conjugation of a peptide to a single long-chain fatty acid like palmitic acid by a thioester or an amide bond. It was found that these S-palmitoylated peptides were much more immunogenic than N-palmitoylated peptides and at least similar to KLH-conjugated peptides with respect to appearance and magnitude of induced antibodies (canine parvovirus) or immunocastration effect (gonadotropin-releasing hormone).Contact us for peptide palmitoylation modification service.
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04/04/2014