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Oligo Synhthesis Scale

What is synthesis scale of an oligonucleotide

Oligo synthesis scale is based on the amount of the first base attached to the solid support to start the oligo synthesis. For larger scales, the amount of solid support is increased. The scale does not indicate the expected yield. Because of the inefficiency of oligonucleotide synthesis and purification, the quantity of DNA ultimately received is usually lower than the theoretical yield.