Can you incorporate unnatural amino acid to my peptide?
Yes, Bio-Synthesis offers hundreds of peptide modification and unatural amino acids incorporation. D-amino acids are the mirror images of the natural L-isomers. Peptide modified with D-amno acids are more stable than peptidecontaining only L-amino acids. These D isomeric amino acids are often used to increase the resistance against a range of degradation enzymes. Study has shown peptide containing D-amino acids have higher biological activity than the natural form. Other unatural amino acids that can be built into peptides are
- Majority of D-amino acid
- D-Orn, Orn, Abu, Aib, (D)1-Nal, (D)2-Pal, (D)4-Cl-Phe, Nva, Nle, Hse, Hcy, Pen, Mpa, N-Methyl amino acid (Ala, Phe, Leu, Ile, Val, Gly, Met), b b-Ala, pGlu, Hyp
- Dinitrobenzoylation (Lys)
- Lys(Me2)
- Phosphorylation (Tyr, Ser, Thr, single site)
- Tyr (SO3H2)
We can also replace the N-H of the amide backbone with N-methyl modified special amino acid, these modified amino acid is useful for destabilizing the formation of secondardy structure and preventing peptide aggregation.
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06/24/2014