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What are ZNA oligonucleotides?

What are ZNA oligonucleotides?

Zip Nucleic Acid (ZNA) is a new class of modified oligonucleotides developed to improve hybridization by decreasing electrostatic replusions due to the polyanionic nature of nucleic acids. This was achieved by conjugating spermine derivatives as cationic moieties (Z units) to an oligonucleotides.

Reference:

  1. Paris, C. et al. (2010) Zip nucleic acids are potent hydrolysis probes for quantitative PCR. Nucl. Acids Res., doi: 10.1093/nar/gkp1218.
  2. Moreau et al. (2009) Zip nucleic acids (ZNAs): new high affinity oligonucleotides as potent primers for PCR and reverse transcription. Nucl. Acids Res., 37: e130; doi:10.1093/nar/gkp661.
  3. Noir, R. et al. (2008) Oligonucleotide-oligospermine conjugates (Zip Nucleic Acids): a convenient means of finely tuning hybridization temperatures. J Am Chem Soc, 130, 13500-13505.
  4. Voirin, E. et al. (2007) Versatile synthesis of oligodeoxyribonucleotide-oligospermine conjugates. Nat Protoc, 2, 1360-1367.