Resuspend or dissolve the RNA after isolation or purification in a buffer suitable for down-stream experiments.
Choose a suitable buffer that minimizes the hydrolysis of RNA. Sodium citrate buffer is an excellent choice for this purpose.
The chelating agent sodium citrate together with a low pH minimizes hydrolysis of RNA.
Use 1.0 mM sodium citrate at pH 6.5.
Alternatively, you can also use 0.1 mM EDTA, or TE buffer, or ultrapure water, however, a citrate buffer it the better choise.
All buffer solutions need to be free of nucleases.
For storage in solution, dissolve the RNA pellet in nuclease-free buffer and store at -80°C.
Avoid multiple freeze-thaw cycles to minimize degradation.