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What is peptide pegylation?

PEG stands for polyethylene glycol, which is an uncharged, hydrophilic and non‐toxic polymer. A mini‐PEG (11‐ amino‐3,6,9‐trioxaundecanoic acid) is useful as a spacer between modifications such as a biotin or fluorescent tag, as it decreases interference in peptide folding and the peptide‐receptor binding interaction. Start your sequence with {mini‐PEG} if you want this spacer before an N‐terminal modification.