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07/09/2007

N-Methyl substituted 29,49-BNANC: a highly nuclease-resistant nucleic acid analogue with high-affinity RNA selective hybridization

Oligonucleotides modified with a novel BNA analogue, 29, 49-BNANC[N–Me], were synthesized, and in comparison to 29,49-BNA (LNA), have similarly high RNA affinity, better RNA selectivity and much higher resistance to nuclease degradation, suggesting that the novel BNA analogue may be particularly useful for antisense approaches.