Enhanced Diagnostic Tools
The last few years have seen a great deal of applications of RNA molecules. Sequence-specific gene silencing using small interfering RNA (siRNA) is a Nobel prize–winning technology that is now being evaluated in clinical trials as a potentially novel therapeutic strategy. As biological researchers move to in vivoexperiments ; there are a few challenges facing siRNA therapeutics, that focus on the delivery strategies for synthetic siRNA duplexes in vivo, as this remains one of the most important issues to be resolved. We at Bio-Synthesis like to highlight the importance of understanding the genocompatibility/toxicogenomics of siRNA delivery reagents in terms of their impact on gene-silencing activity and specificity. Collectively, this information is essential for the selection of optimally acting siRNA delivery system combinations for the many proposed applications of RNA interference.
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