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Antisense oligonucleotides are synthetic polymers in which some or all of the natural nucleotide monomers of the oligonucleotide are chemically-modified deoxynucleotides (in DNA) or ribonucleotides (in RNA). In antisense technology, single-stranded DNA or RNA molecules are used to target a specific sense mRNA. Normally, antisense oligonucleotides contain 15 to 22 monomers and are often called "oligos". The use of antisense oligonucleotides was first identified over twenty years ago as a method to arrest gene expression levels, both in vitro and in vivo. However, antisense compounds have now become effective tools useful in basic molecular biology, genomics, and proteomics research, often used for target screening and validation as well as for drug discovery. For example, antisense oligonucleotides can act by blocking the upstream message for receptor substrates, proteins over-expressed in pathological versus physiological states. Antisense technologies utilize single-stranded fragments of DNA that bind mRNA to form a duplex. The formation of the duplex, or double-stranded molecule, prevents the mRNA from being translated into protein and producing the downstream protein signal. Antisense oligonucleotides therefore are able to reduce the upstream signaling of protein expression and can concomitantly normalize the downstream expression of the targeted protein. It is thought that by blocking the expression of selected proteins in signaling cascades, unwanted side effects may be avoided when using antisense oligonucleotides.
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A minimum charge will apply for oligos of <10 bases. Yields and base price may vary depending on type of antisense synthesis..
Contact us for scale >10 umol