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Small-Molecule Functional Tags

Add bioactive small molecules to DNA/RNA—puromycin, doxorubicin, cisplatin, folate, methotrexate, tocopherol, ferrocene, TEMPO, anthraquinone, psoralen—for display, delivery, sensing, and crosslinking. Product & notes panels include nested Technical Notes.

ISO 9001:2015 / ISO13485:2016 45+ Years of Expertise U.S.A. Facilities-Texas GLP/GMP-Aligned
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Overview Product & Notes Related FAQ Speak to Scientist

Overview — Functional Small-Molecule Oligo Tags

Small-Molecule Functional Tags expand oligonucleotide utility beyond dyes and peptides. We custom-conjugate puromycin, doxorubicin, cisplatin, folate, methotrexate, tocopherol, ferrocene, TEMPO, anthraquinone, psoralen and more to DNA/RNA for **mRNA display**, **oligo–drug conjugates**, **targeted delivery**, **electrochemical sensing**, and **UV crosslinking**.

Bio-Synthesis provides design support (linker selection, placement), scalable synthesis (nmol→gram), and ISO-aligned QC (HPLC, ESI-MS; optional CE/SEC & functional tests). See also: Spacer & Linker • Oligo Bioconjugation • Quencher Compatibility.

Display & Selection Oligo–Drug ConjugatesElectrochemical Targeted Delivery ISO 9001/13485

Product & Notes

Hide Products and Notes
Product Description Application Code
Puromycin Aminonucleoside antibiotic; mimics aminoacyl-tRNA mRNA display / RaPID peptide–RNA fusion [Puromycin]
Doxorubicin Anthracycline intercalator chemotherapeutic Oligo–drug conjugates for targeted delivery [Dox]
Cisplatin Pt(II) DNA-binding complex Drug–oligo conjugates; DNA adduct formation [Pt-DNA]
Folate Folic acid / Vitamin B9 ligand Target folate receptor–positive cells [Folate]
Methotrexate Antimetabolite / antifolate DHFR recruitment; receptor targeting [MTX]
Tocopherol (Vit E) Hydrophobic vitamin; lipid-like conjugate Uptake enhancement; serum binding [Toco]
Ferrocene Organometallic redox reporter Electrochemical aptamer/probe sensors [Fc]
TEMPO Nitroxide spin label EPR/paramagnetic readouts, dynamics [TEMPO]
Anthraquinone Aromatic redox / PET chromophore Electron transfer; photoinduced assays [AQ]
Psoralen Photo-intercalator; UV crosslinker Trap NA–NA/NA–protein interactions [Psor]
Estradiol / Retinoic Acid / Vit D Hormone/vitamin ligands Receptor targeting; uptake studies [Ligand]
Show Technical Notes
  • Placement & Linkers: Keep bulky/drug tags near termini; use TEG/HEG/PEG to reduce sterics and preserve hybridization.
  • Puromycin: Typically 3′-attached with a flexible linker for efficient peptide transfer in mRNA display.
  • Electrochemical Tags: Ferrocene/AQ signals depend on buffer and surface; keep solutions metal-free and verify by cyclic voltammetry.
  • Tocopherol/Folate: Consider PEG spacers to balance hydrophobicity and solubility.

FAQ

What is a small molecule functionalized oligonucleotide?
It is a DNA or RNA oligonucleotide modified with a small molecule that adds a function beyond sequence recognition, such as detection, affinity capture, delivery, targeting, surface attachment or sensing.
Which small molecules can be attached to oligonucleotides?
Examples include fluorophores, quenchers, biotin, desthiobiotin, cholesterol, GalNAc, lipids, redox labels, chelators, affinity tags, targeting ligands and customer-supplied molecules.
Can customer-supplied molecules be evaluated?
Yes. Customer-supplied molecules can be reviewed for functional groups, solubility, stability, linker strategy, synthesis feasibility, purification and analytical confirmation.
What linker options are commonly used?
Common options include C3, C6, C12, TEG, PEG-style spacers and specialty linkers. The linker controls distance, flexibility, accessibility and sometimes solubility.
Should the small molecule be placed at the 5′ end, 3′ end or internally?
Placement depends on the intended function. Terminal placement is often used for labeling or capture, while internal placement may be needed for structure-sensitive probes or specialized assay formats.
Does hydrophobicity affect synthesis or purification?
 Yes. Hydrophobic molecules such as cholesterol, lipids, dyes and some payloads can affect coupling efficiency, solubility, HPLC behavior and final recovery.
Can multiple modifications be combined?
 Yes. Small molecule modifications can often be combined with fluorophores, quenchers, biotin, thiols, click handles, spacers or backbone/base modifications when compatibility is reviewed.
Are these oligos suitable for therapeutic research?
 Small molecule functionalized oligos are frequently used in research-stage delivery, targeting and therapeutic-conjugate studies. Final design should be reviewed around application, purity and documentation needs.
How are small molecule oligo conjugates purified?
 Purification may include desalting, cartridge, PAGE or HPLC depending on modification type, hydrophobicity, oligo length, scale and required purity.
How is conjugation or modification verified?
 Analytical HPLC, UPLC and mass spectrometry are commonly used to confirm identity and purity when appropriate for the modification and product format.
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