Custom DNA and RNA oligonucleotides functionalized with small-molecule tags, ligands and bioactive molecules for sensing, targeting, delivery, crosslinking, display technologies and specialized research applications.
Small-molecule functionalization expands the capabilities of DNA and RNA oligonucleotides beyond sequence recognition alone.
By attaching bioactive molecules, targeting ligands, sensing groups or specialized chemical tags, oligonucleotides can be adapted for advanced research applications including molecular display, delivery studies, electrochemical sensing, photo-crosslinking, affinity workflows and oligo-drug conjugate development.
Bio-Synthesis supports standard and custom small-molecule oligo modifications including puromycin conjugates for mRNA display and selection technologies, folate, tocopherol, retinoic acid, estradiol, vitamin D, ferrocene, TEMPO, anthraquinone, psoralen, drug-like payloads and customer-supplied specialty molecules.
Fluorophores, quenchers and near-IR labels add readable signal for qPCR probes, beacons, hybridization assays and imaging workflows.
Biotin, desthiobiotin and affinity tags support pull-down, enrichment, immobilization and assay capture formats.
Cholesterol, lipids and delivery ligands can help explore uptake, biodistribution, formulation and cell-association behavior.
GalNAc, peptides and receptor-binding ligands can be positioned to support tissue, receptor or cell-directed research designs.
Ferrocene, methylene blue and other redox labels can convert target binding into electrochemical or surface-based signal output.
Thiol, affinity and anchoring groups help attach oligos to beads, plates, arrays, electrodes and biosensor surfaces.
Bio-Synthesis supports small-molecule tag and bioactive conjugate classes used in advanced oligonucleotide research, including mRNA display, oligo-drug conjugates, targeting, sensing, photo-crosslinking and custom assay development.
Small-molecule tags used to connect oligonucleotides with translated products or selection workflows.
Explore Puromycin & mRNA Display →
Bioactive molecules used to explore oligo-drug conjugates, targeted delivery and payload-linked research constructs.
Explore oligo-drug conjugates →
Small-molecule ligands designed to support receptor recognition, uptake studies and delivery-oriented oligo research.
Explore targeted delivery →
Electroactive tags that convert oligonucleotide recognition or surface binding into measurable analytical signals.
Explore redox labels →
UV-reactive small molecules used to capture nucleic-acid interactions or stabilize interaction states.
Explore cross-linking bases →
Customer-supplied and proprietary molecules reviewed for conjugation feasibility, linker strategy and purification planning.
Explore custom bioconjugation →
The best small-molecule oligo design depends on whether the molecule is acting as a tag, ligand, payload, sensor reporter, crosslinker or custom research handle.
Successful small molecule functionalization requires careful consideration of conjugation site, linker selection, molecular properties and intended application. These factors can influence oligonucleotide accessibility, solubility, purification strategy, analytical characterization and overall performance within a research workflow.
Bioactive small-molecule payloads can be attached to oligos for early-stage oligo-drug conjugate and delivery research.
Explore Service →
Folate, tocopherol and related ligands support receptor-targeted and delivery-oriented oligonucleotide research.
Redox tags and reporter small molecules support electrochemical biosensors, molecular detection and diagnostic assay development.
Puromycin and display-oriented tags support mRNA display, library screening and selection workflows.
Psoralen and related photoactive small molecules enable nucleic acid interaction studies and UV-triggered crosslinking workflows.
Customer-supplied molecules and proprietary compounds can be reviewed for custom oligo functionalization feasibility.
Small molecules can be reviewed for 5′, 3′ or internal placement based on oligo design and application.
Spacer architecture is selected around accessibility, hydrophobicity, steric effects and final function.
HPLC, UPLC and mass spectrometry options support identity and purity confirmation.
Customer-supplied molecules can be evaluated for functional groups, solubility and conjugation feasibility.
Scale, purification and documentation can be aligned with research, diagnostic or development needs.
Experience supporting oligonucleotide conjugation with bioactive molecules, targeting ligands, redox reporters, photo-crosslinkers and customer-supplied compounds.
Explore major small molecule modification categories.
Include molecule, sequence, position, linker, scale, purity and application.
Selected references covering oligonucleotide conjugates, ligand-conjugated oligonucleotide therapeutics, nucleic acid functionalization and targeted delivery. These citations are provided for scientific background and design context rather than product-performance claims.
Note: Small molecule functionalization should be selected around sequence design, conjugation site, linker architecture, solubility, purification, analytical verification and final application. Literature references provide general context and should be evaluated within the specific research workflow.
Trusted by biotech leaders worldwide for over 45+ years of delivering high quality, fast and scalable synthetic biology solutions.