Custom sugar-modified RNA and DNA oligonucleotides — including 2′-OMe, 2′-F, MOE, LNA/BNA, cEt, UNA, FANA, and 4′-Thio — engineered for enhanced stability, nuclease resistance, binding affinity, and therapeutic research performance.
Bio-Synthesis provides a complete portfolio of sugar-modified nucleotides for custom DNA and RNA oligonucleotide synthesis. By tailoring the ribose/deoxyribose scaffold with chemistries such as 2′-O-methyl, 2′-fluoro, MOE, LNA/BNA, cEt, UNA, FANA, 4′-Thio, and stereochemical variants, researchers can fine-tune hybridization, nuclease resistance, pharmacokinetics, and protein interactions.
2′-substitutions improve nuclease resistance and pharmacokinetics; locked and bridged sugars boost binding affinity and potency; and flexible analogs introduce conformational freedom for structural biology and probe design. These edits can be combined with PS backbones, conjugates, or terminal caps to balance activity, safety, and durability.
Improve resistance to nucleases and extend functional lifetime in biological environments.
Increase or tune duplex melting temperature for ASO, siRNA, qPCR, and probe applications.
Use sugar chemistry, backbone design, and conjugates to tune pharmacology and durability.
Design gapmers and steric-blocking oligos with modification placement matched to mechanism.
Sugar edits tune nuclease resistance, duplex Tm, protein interactions, and innate sensing. Common strategies include 2′-OMe/2′-F/MOE, conformational locks such as LNA/BNA/cEt/ENA, and alternative frameworks such as FANA, TMO, SNA, TNA, and GNA.
Deoxy and stereochemical variants such as 2′-F-dN, ara-dN, and 2′-amino modifications modulate duplex geometry and nuclease sensitivity; dI supports wobble or degenerate pairing.
Constrained sugar rings such as LNA/BNA and related bridged systems constrain the ribose structure, delivering large per-residue Tm gains and potent binding — ideal for short probes and ASO wings.
UNA, GNA, HNA, CeNA, and TNA frameworks tune backbone flexibility and helix geometry, supporting structure probing, specificity control, synthetic biology, and XNA research.
Support sugar-modified oligo design, synthesis, conjugation, purification, formulation, and delivery workflows with related Bio-Synthesis services.
2′-OMe/2′-F/LNA patterns, duplex design, and scale-up support.
Gapmer and steric-block architectures with PS/PN backbone options.
Modified bases, long RNA, capping, poly(A), and RNA workflow support.
High-affinity probes and antisense analogs.
Steric-block splice modulation tools.
Microfluidic scalable formulation for RNA and ASO programs.
Explore supporting services for sugar-modified oligo design, synthesis, conjugation, purification, and delivery.
Include oligo type, sequence length, modification pattern, backbone, conjugations, purification target, QC needs, and timeline.
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