Radiolabel-compatible peptide chelator conjugates are non-radioactive peptide constructs in which a
metal-chelating ligand is covalently attached to a peptide to enable downstream coordination of radiometals.
These constructs are commonly used as radioligand precursors for imaging and tracer-development workflows
(project-dependent).
In this workflow, Bio-Synthesis provides the chelator-enabled peptide precursor (purified and analytically confirmed),
while radiolabeling is performed by the end user in an appropriate radiochemistry setting.
Bio-Synthesis does not perform radiolabeling or handle radioactive materials.
Compared to radiochemistry-focused vendors, Bio-Synthesis specializes in the upstream synthesis of non-radioactive peptide–chelator conjugates, enabling researchers to control peptide sequence, attachment site, and chelator architecture before radiolabeling.
Successful chelator–peptide designs depend on chelator class (macrocyclic vs acyclic), attachment site selection,
and spacer/linker strategy to maintain peptide binding and improve handling. We support representative chelators including
DOTA, DO2A, DO3A, DOTP, TACN, NOTA,
and TETA, and we can evaluate user-specified chelators (project-dependent).
Peptide–chelator conjugates
Radioligand precursors
Macrocyclic chelators
Acyclic chelators (evaluation)
Site-defined attachment
Non-radioactive service
Radiolabel-compatible peptide–chelator conjugate architecture (non-radioactive chelator-enabled precursor; radiolabeling performed downstream by end user).