40+ years of excellence in custom synthesis and bioconjugation services.
Calculators, design tools, and educational content to support your research.
Find the right chemistry—by property or function.
Scan the landscape of modification types and quickly jump to what you need—probe chemistries, hybridization control, nuclease stability, intercalators, universal bases, metal chelates, redox labels, and more. All options are available with expert design support, scalable manufacturing, and full QC.
Structured DNA/RNA ligands for SELEX-ready libraries with high-affinity binding to proteins, cells, or small molecules; ideal for capture, imaging, and therapeutics.
Binding Explore
Biotin/streptavidin capture, Dig/DNP detection, His-tag style NTA-Ni binding for pull-down, detection, or immobilization in ELISA, lateral flow, and biosensor.
Capture Explore
Environment-sensitive bases and dark reporters for label-free detection, hybridization monitoring, or FRET acceptors without emission.
Sensing Explore
Photocleavable or chemically cleavable dye linkers for background suppression, release assays, and spatiotemporal activation.
Caged Explore
G-quadruplex, triplex-forming, and structural stabilizers to control folding, topology, and higher-order organization. Supports aptamer stability and nanostructure design.
Structure Explore
Protected, reactive bases that are transformed post-synthesis to introduce custom functional groups at defined positions for bioconjugation.
Reactive Explore
Isotopically labeled nucleotides (²H) for mechanistic studies, mass-spectrometric tracing, and pharmacokinetic profiling.
Isotope Explore
Reversible photochromic units (e.g., azobenzene) to modulate Tm or hybridization singal, conformation. Supports photo-gating and logic circuits.
Photo Explore
Wobble/ambiguous bases (e.g., inosine, mixed bases) to accommodate variability in target sequences and library design. Balance degeneracy with specificity using modeling support.
Wobble Explore
LNA/BNA/cEt, MOE and related chemistries to tune Tm, mismatch discrimination, and clamping for PCR/ASO/antisense. Backbones: PS, PM, PN to increase stability and binding half-life.
Tm Control Explore
Planar aromatic intercalators (psoralen, acridines, naphthalimides, YO/YOYO) for crosslinking, stabilization, and imaging.
Intercalate Explore
EDTA/DTPA/NTA and custom chelators for radiometals, lanthanides, or catalytic cleavage mapping. Lanthanide/ radiometal labeling for TR-FRET or SPECT/PET tracers.
Chelation Explore
Backbone and sugar chemistries (PS, PM/PN, 2′-OMe, 2′-F, LNA/BNA, cEt) and terminal caps to enhance in vitro/in vivo durability. Sugar variants (2′-OMe, 2′-F, LNA/BNA, cEt, UNA) for ASO/siRNA.
Stability Explore
NOMP-dT, DEACM cages for light-triggered activation, cleavage, or release. Ideal for spatiotemporal control in cells or materials.
Light Explore
Indole/5-nitroindole and related analogs that pair non-specifically to enable mixed templates or degenerate priming. Useful in degenerate primers and mixed templates.
Universal Explore
Tell us your assay, instrument, scale, and QC needs. We’ll propose the optimal base, backbone, or label with delivery timeline and quote.
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