Custom DNA and RNA oligos carrying DOTA, NOTA, DTPA, DFO, CB-TE2A, DPA, Eu/Tb and specialty chelators for PET/SPECT radiolabeling, MRI contrast, TR-FRET, phosphate-recognition probes and metal-mediated assay development.
Bio-Synthesis supports custom chelator-modified oligonucleotides for PET/SPECT radiolabeling, MRI contrast research, lanthanide time-resolved fluorescence, metal-mediated capture and phosphate-recognition probe workflows.
Chelators can be installed through NHS ester, isothiocyanate, maleimide, azide/alkyne click or other reactive handles at the 5′ end, 3′ end or selected internal positions. PEG/TEG linkers are often used to reduce steric effects and preserve hybridization.
Common chelator families include DOTA/NOTA/DTPA, CB-TE2A, DFO, DPA, and Eu/Tb lanthanide chelates. The best choice depends on the metal ion or isotope, labeling conditions, complex stability, assay format, oligo placement and downstream purification/QC plan.
Animated flow shows how the oligonucleotide, chelator handle and metal readout are selected as one connected design system.
The core chelator table from the live page is reorganized as a practical selection guide by chelator family, common reactive forms, metals, application and design note.
Choose the chelator around the metal isotope, complex stability, labeling temperature, oligo backbone and final application.
Technical notes: Prefer terminal placement when possible to minimize helix perturbation. Use short PEG/TEG linkers to reduce steric effects. For radiometal work, maintain mild metal-compatible buffers and confirm both apo- and metal-loaded states when required.
Smaller chelators are useful for phosphate recognition, optical probes, bacterial membrane targeting and long-lifetime Eu/Tb time-resolved fluorescence labels.
Use compact probe chelators when the goal is sensing, recognition or optical readout rather than long-term in-vivo radiometal retention.
Probe notes: DPA is compact and useful for phosphate-rich surfaces, but it is not the same as macrocyclic radiometal chelators. Lanthanide tags require compatible buffers and avoidance of competing chelators such as EDTA during assays.
Start with the metal or assay readout, then refine by labeling conditions, stability requirement and oligo architecture.
NOTA, TRAP/DATA, DOTA depending on kinetics and labeling conditions.
DOTA-based chelators for radiotherapy-oriented workflows.
DFO or DFO derivatives for zirconium-based labeling.
DTPA-Eu/Tb or cyclen/cyclam lanthanide tags.
Zn-DPA motifs for phosphate-rich surfaces and responsive probes.
Chelator-modified oligos are used when nucleic acid recognition must be combined with radiometal labeling, metal-mediated sensing, lanthanide emission or metal-dependent capture.
Radiometal-labeled oligos for imaging and tracer development studies.
Gd/DTPA-style and metal-chelate oligos for contrast and multimodal probe design.
Eu/Tb chelates for long-lifetime fluorescent labels and time-resolved detection.
Zn-DPA motifs for phosphate-rich surfaces, membrane targeting and responsive probes.
Chelator-oligo intermediates for antibody, peptide, protein or nanoparticle conjugates.
Metal-binding probe designs for capture, purification, assay development and sensing.
Explore connected modified oligo and bioconjugation services.
Include sequence, chelator, metal, position, scale, purification and QC.
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