Overview
Reactive Base Scaffolds for Post-Synthetic Oligo Engineering
Convertible base modified oligonucleotides incorporate nucleobases engineered to be transformed after synthesis or to provide a reactive leaving group at a defined position. These scaffold bases are used to install probes, form crosslinks, mimic DNA/RNA lesions, or introduce epigenetic marks at precise sites.
Instead of building every functionality directly during solid-phase synthesis, a convertible base provides a single addressable site for post-synthetic functionalization. This allows fluorophores, quenchers, biotin, click handles, affinity tags, crosslinking groups, or lesion-like analogs to be installed with greater flexibility.
Bio-Synthesis supports convertible base design, synthesis, conversion, purification and analytical confirmation
for research-use oligonucleotide programs requiring defined site-specific functionality.
Bio-Synthesis manufactures convertible base modified DNA and RNA oligonucleotides incorporating reactive pyrimidine, purine, halogenated, sulfur-containing, and epigenetic nucleobase analogs with optional HPLC purification, LC-MS confirmation, and custom post-synthetic functionalization workflows.
Convertible Leaving Groups
Halogenated Bases
Epigenetic Marks
Mutagenesis Tools
QC: HPLC / LC-MS
Convertible Base
Reactive scaffold placed at a defined sequence position.
Chemical Conversion
Substitution, click, crosslinking or defined base modification.
Custom Functionality
Dye, biotin, linker, ligand, lesion or crosslinking handle.
Research Application
Probe engineering, interaction mapping, epigenetics or repair studies.