Overview
What Are Metal-Chelating Oligonucleotides?
Metal-chelating oligonucleotides are DNA or RNA molecules modified with a chelator or metal-binding ligand capable of coordinating metal ions such as lanthanides, transition metals, radiometals, or MRI contrast metals. By combining nucleic acid sequence recognition with metal-binding chemistry, researchers can create probes for molecular imaging, biosensing, affinity capture, and metal-mediated nucleic acid assembly.
Bio-Synthesis supports both traditional chelator conjugates, including DOTA, NOTA, DTPA, EDTA and NTA, and metal-ligand oligonucleotides, including bipyridine, terpyridine and phenanthroline derivatives. Services include custom DNA/RNA synthesis, chelator conjugation, purification, analytical QC, optional metal-loading checks and RUO → GMP-like documentation.
Bio-Synthesis supports custom DOTA oligonucleotide, NOTA oligonucleotide, DTPA oligonucleotide, lanthanide oligonucleotide, radiometal-labeled oligonucleotide, NTA oligonucleotide conjugate, metal-chelating DNA, and metal-chelating RNA synthesis projects for imaging, sensing, affinity capture and molecular assembly applications.
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CHEMISTRIES
DOTA • NOTA • DTPA • NTA
M
METALS
Lanthanides • Radiometals • Ni²⁺
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FORMATS
DNA • RNA • Conjugates