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Research-Grade Oligonucleotide Synthesis

Custom research-grade oligonucleotide synthesis for advanced molecular biology, genomics, and diagnostic research workflows.

45+ Years of Expertise ISO 9001:2015 / ISO 13485:2016 Bench to Kilo Scale Confidential & IP-Protected U.S.A Facilities - Texas

Research-Grade oligonucleotides designed around your research workflow

OligoLS™ supports molecular biology, assay development, discovery research, and diagnostic development workflows where sequence accuracy, modification flexibility, purification strategy, and analytical confidence matter.

PCR Primers, qPCR Probes, NGS Oligos, CRISPR Guide RNA, and Research Probes

PCR Primers qPCR Probes NGS Adapters CRISPR Guide RNA Molecular Beacons FISH Probes siRNA Research Synthetic Biology

Built for reliable research performance, not just oligo ordering

OligoLS™ is designed for research teams that need dependable oligonucleotide synthesis, flexible chemistry options, and practical technical support for assay-driven molecular biology workflows.

Application-aware synthesis

Oligos can be specified around the actual research workflow, not only sequence and scale.

  • PCR, qPCR, NGS, CRISPR, probe, and diagnostic research support
  • Application-driven recommendations for purification and QC
  • Support for standard and complex oligo designs

More confidence downstream

Better alignment between synthesis, purification, modification, and application can reduce troubleshooting during downstream experiments.

  • Options for HPLC, PAGE, cartridge, or desalt purification
  • Analytical support for identity and purity expectations
  • Useful for assay-sensitive and modification-heavy projects

Specialty chemistry access

Bio-Synthesis supports modified, labeled, conjugated, and difficult oligo designs that basic catalog-style ordering systems may not handle well.

  • Fluorophores, quenchers, linkers, biotin, thiol, amino, and specialty groups
  • Backbone, base, sugar, and terminal modifications
  • Pathway to scale-up or development support when needed

Modified DNA and RNA Oligonucleotide Chemistry

Bio-Synthesis supports standard and specialty oligonucleotide modifications to help researchers design oligos for detection, binding, stability, conjugation, imaging, sequencing, and functional studies.

Modified Oligonucleotides for Detection, Stability, Labeling, and Conjugation

Labels & Detection

  • Fluorescent dyes
  • Quenchers
  • Dual-labeled probes
  • Biotin and affinity tags

Linkers & Functional Groups

  • Amino modifications
  • Thiol modifications
  • Spacer and linker chemistry
  • Click-ready handles

Backbone & Base Modifications

  • Phosphorothioate linkages
  • Modified bases
  • 2′ modifications
  • Stability-oriented designs

Research-Grade Oligonucleotide Purification & QC Options

Research-grade oligos can require different purity, yield, and analytical strategies depending on application, length, modification, and assay sensitivity.

Desalt, Cartridge, PAGE, HPLC, and Analytical QC Support

Option Best For Why It Matters
Desalt Standard primers and routine molecular biology use. Cost-effective option for many PCR and basic research workflows.
Cartridge / RP Purification Moderate purity needs and selected modified oligos. Improves product quality for assays that need better cleanup than desalt.
PAGE Purification Longer oligos, sequence-sensitive applications, and higher-resolution separation. Helps isolate full-length product from truncated synthesis products.
HPLC Purification Modified oligos, probes, labeled oligos, and demanding assay workflows. Supports improved purity for complex or high-value research applications.
Analytical QC Identity, purity, and documentation support. Provides confidence for downstream research performance and troubleshooting.

Research Oligonucleotide Synthesis Workflow

OligoLS™ supports researchers with flexible synthesis, modification, purification, and analytical workflows designed for advanced molecular biology applications.

CDMO capabilities workflow from research and discovery to custom synthesis, chemistry development, and therapeutic development
Research → Chemistry Development → Therapeutic Development

Why Choose Bio-Synthesis for Research-Grade Oligonucleotide Synthesis

Bio-Synthesis combines research-use oligonucleotide synthesis with deeper custom chemistry capabilities, helping scientists move from routine primer ordering to more complex modified, labeled, conjugated, and assay-critical oligo designs.

45+
Years of Expertise

Long-standing custom synthesis experience supporting biotechnology, pharmaceutical, diagnostic, and research organizations.

ISO

Quality-focused workflows for research-use oligonucleotide synthesis, documentation, and customer support.

DNA/RNA
Custom Oligos

Support for standard, modified, labeled, conjugated, and assay-critical oligonucleotide designs.

QC
Analytical Support

Purification and analytical options matched to routine primers, sensitive probes, modified oligos, and demanding assay systems.

Research-Grade Oligonucleotide Synthesis FAQ

Common questions about OligoLS™ research-use oligos, modification options, purification choices, and when to request technical guidance.

FAQ

What are research-grade oligonucleotides?
Research-grade oligonucleotides are custom DNA or RNA oligos manufactured for research-use workflows such as PCR, qPCR, NGS, CRISPR, probe development, assay development, and molecular biology studies.
Can Bio-Synthesis synthesize modified oligos?
Yes. Bio-Synthesis supports fluorescent labels, quenchers, biotin, linkers, amino and thiol modifications, modified bases, backbone modifications, conjugation-ready handles, and other application-specific designs.
Which purification option should I choose?
The best purification depends on your oligo length, modification, purity requirement, and application. HPLC or PAGE is often recommended for modified, long, labeled, or assay-critical oligos, while desalt may be sufficient for routine primers.
What applications are RUO oligos suitable for?
OligoLS™ RUO oligos can support PCR, qPCR, NGS, CRISPR, gene editing research, molecular diagnostics research, FISH probes, molecular beacons, antisense research, RNA research, assay development, and synthetic biology workflows.
Can I request help choosing modifications or QC?
Yes. If your oligo includes labels, quenchers, linkers, modified bases, conjugation handles, longer sequences, or sensitive downstream assays, Bio-Synthesis can help match your design with appropriate purification and analytical support.
Are these oligos intended for therapeutic use?
OligoLS™ RUO oligos are intended for research use. If your project requires therapeutic development, scale-up, or regulated manufacturing support, Bio-Synthesis can discuss the appropriate development pathway.

Discuss Your Research Oligonucleotide Project

Share your sequence, modification, purification, scale, and application requirements. Bio-Synthesis can help align custom DNA and RNA oligonucleotide synthesis with your research workflow.
DNA & RNA Oligos
Modifications & Labels
Purification & QC
Partner with a leader in custom synthesis CDMO solutions and therapeutic development support

Need Design Guidance?

Discuss modifications, purification strategies, long oligos, probes, or application-specific synthesis requirements with our scientific team.

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Know Your Sequence?

Submit sequence, scale, modification, purification, and delivery requirements for project review.

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Why Choose Bio-Synthesis

Trusted by biotech leaders worldwide for over 45+ years of delivering high quality, fast and scalable synthetic biology solutions.