Guaranteed Quality
At Bio-Synthesis, we pride ourselves on our reputation for high quality nucleic
acid synthesis.
As part of our long-standing commitment to quality, we employ the following standards
for quality assurance:
- All nucleic acid synthesis products (including RNA, siRNAs, DNA, PNA) are analyzed
by mass spectrometry and quantified at least twice by uv spectrophotometry (unless
no post-synthesis processing is requested)
- MALDI-TOFMS for all standard DNA, RNA, siRNA and PNA synthesis
- ESI-MS for all longer or highly modified oligonucleotides
- HPLC, PAGE, RNase Free HPLC and PAGE for purification of DNA and RNA products
- UPLC or CGE for quality analysis when appropriate
- Custom QC methods and documentation are available upon request
Quality control documentation available upon request includes:
- Mass Spectrometry traces
- UPLC or CGE analysis
- Duplex or individual strand purity analysis
- Certificate of Analysis
- Endotoxin certification
- Custom QC documentation
For all mid-scale synthesis projects (200 mg - 10 g), we adhere to a stringent manufacturing
process:
- HPLC purification highly recommended to achieve optimal purity
- Tangiential Flow Filtration (TFF) utilized for premium salt removal
- Batch records maintained on all synthesis projects (we follow GMP guidelines, but
are not GMP certified)
- Endotoxin testing included on all mid-scale orders
- Data deliverables include MS, UPLC, endotoxin results, and a certificate of analysis
If you are dissatisfied and report an oligo problem within 30 days of order receipt,
we will gladly remake your oligo free of charge or provide a credit for the purchase
amount.