Salt & Sodium Content Analysis by ICP for Oligonucleotides, Peptides, Proteins, and Biologics

Sodium Content

Sodium analysis is commonly requested for oligonucleotides, peptides, and purified biomolecules where counterion or residual salt content must be estimated.

Residual Salts

ICP analysis can help evaluate inorganic salt residues from synthesis, purification, buffer exchange, or formulation workflows.

Elemental Screening

Selected elemental analysis may be performed for sample characterization or project-specific analytical support.

What the analysis can provide

• Element-specific concentration data
• Sodium or selected ion content
• Residual inorganic salt information
• Support for product characterization

Important considerations

• Results depend on sample matrix and concentration
• Some buffers or excipients may contribute background ions
• Sample preparation may be required before analysis
• Project-specific acceptance criteria should be provided when available

Recommended information

• Sample type and molecule name
• Expected concentration or total amount
• Buffer composition and pH
• Known salt form or counterion, if available
• Common analyses include sodium, potassium, acetate, and residual counterion assessment
• Target element or requested analysis
• Required reporting units, if specified
• Recommended submission amount: approximately 10 mg per test

Handling recommendations

• Submit purified material whenever possible
• Use clean, contamination-free containers
• Avoid unnecessary salts or metal-containing additives
• Clearly label all submitted samples
• Ship temperature-sensitive samples appropriately
• Contact us before submitting unusual matrices