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Modified oligonucleotides (modified DNA and RNA) are essential tools for understanding and manipulating biological processes. Bio-Synthesis Inc. is a leading provider of custom oligonucleotide modifications services, offering a wide range of modifications to meet your specific needs. Oligonucleotide modifications can transform ordinary oligonucleotides into potent antisense oligonucleotides (ASOs), splice-switching oligonucleotides (SSOs), small interfering RNA (siRNA), and RNA aptamers. Unleash the full potential of your research and explore the possibilities with oligonucleotide modifications.

Our integrated FlexOligo Synthesis platform results in significant cost savings and allows for rapid scale-up production. We specialize in complex oligonucleotide modifications, including backbone modifications, base modifications, and fluorescent dye labeling. Our modified oligonucleotides are synthesized to the highest quality standards and are used in a variety of research and diagnostic applications.

Why choose Bio-Synthesis Inc. for your oligonucleotide modifications needs?

  • Wide range of chimeric and fully modified modifications including:
    • Backbone modifications: phosphorothioate linkages, methylphosphonate linkages, phosphoryl guanidium linkages, locked nucleic acids (LNAs), thio morpholino oligonucleotides (TMOs) and peptide nucleic acids (PNAs)
    • Base modifications: 2'-O-methyl, 2'-O-fluoro, 2’ MOE and other base modifications to improve nuclease stability and affinity
    • Fluorescent dye labeling: a wide range of fluorescent dyes available to meet your specific detection needs
    • Bioconjugations: Lipid-oligo conjugation and Peptide-oligo conjugation
  • Custom synthesis services: we can synthesize modified oligonucleotides of any length or sequence to meet your specific needs
  • High quality standards at competitive pricing
  • Rapid turnaround

If you are unable to find your desired product please contact us for assistance or send an email to info@biosyn.com

You may retrieve a modified oligonucleotide by performing a product search or by clicking the tabs below to view an alphabetical list all the modified oligonucleotides.

If you are unable to find your desired product please contact us for assistance or send an email to info@biosyn.com

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Welcome To Biosynthesis - Oligonucleotide Modification Products
>Backbone Modified Oligos
>Cross-Link Base Modified Oligos
>Dendrimer Branch Oligo Synthesis
>Enzyme Oligo Labeling Services
>Inverted Base Modified Oligos
>Janelia Fluor Dyes
>Phosphorylated Oligos
>Photocleavable Modified Oligonucleotide Synthesis
>Spacer Modified Oligonucleotide Synthesis
>Terminal Cap
2' Deoxynebularine, dN Oligonucleotide Modification
2' Fluoro RNA Modification
2' O-Methyl RNA (2' Me) Synthesis
2' Phosphate Oligonucleotide Modification
2' Thiophosphate Oligonucleotide Modification
2,2′-Dipicolylamine (DPA) Oligo Modification
2',2'-Difluorodeoxycytidine (Gemcitabine) dFdC Modified Oligo
2',3'-Dideoxyadenosine, ddA Oligonucleotide Modification
2',3'-Dideoxycytidine, ddC Oligonucleotide Modification
2',3'-Dideoxyguanosine, ddG Oligonucleotide Modification
2',3'-Dideoxythymidine, ddT Oligonucleotide Modification
2,6-Diaminopurine-2'-deoxyriboside (DAPdR) Oligonucleotide Modification
2,6-Diaminopurine-2'-O-methylriboside Oligonucleotide Modification
2,6-Diaminopurine-riboside Oligonucleotide Modification
2',7'-Dichloro- fluorescein
2-Aminopurine-2'-deoxyriboside Oligonucleotide Modification
2-Aminopurine-2'-O-methylriboside Oligonucleotide Modification
2-Aminopurine-Ribose Oligonucleotide Modification
2'-Deoxycytidine-5-C6 Amino Linker (Amino C6-dC)
2'-Deoxyguanosine-8-C6 Amino Linker (2'-dG-C6-NH2)
2'-Deoxyinosine Oligonucleotide Modification
2'-Deoxyisoguanosine
2'-Deoxypseudouridine Oligonucleotide Modification
2'-Deoxyuridine
2'-F-arabinonucleic acid (2'-F-ANA) Oligonucleotides
2-Fluoro deoxy Inosine dl (convertible dG) Oligonucleotide Modification
2'-MOE, 2-MethoxyEthoxy, RNA Modification
2'-O-Methylinosine, 2'-OMe-I Oligonucleotide Modification
2-Thiothymidine Oligonucleotide Modification
3' Carboxy Linker Oligonucleotide Modification
3' Phosphate Oligonucleotide Modification
3' Thiol C3 Linkers
3' Thiophosphate Oligonucleotide Modification
3' Uaq Cap
3'-3' Reverse Linked Oligonucleotide
3-Cyano-7-Ethoxycoumarin Oligo Labeling
3-cyanovinylcarbazole nucleoside CNVK Ultrafast Photo Cross-Linker
3-deaza-2'-deoxyadenosine, 3-deaza-dA
3-Deaza-5-Aza-2'-O-methylcytidine Oligonucleotide Modification
3'-Deoxyadenosine, Cordycepin,2'-5' Linked Oligonucleotide Modification
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Why Choose Bio-Synthesis

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