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PNA Synthesis Services

BSI explicit commitment to long-term continuous R&D development has develop a cost-effective method of synthesize your PNA at multiple size and scale with wide range of modifications with SPEED, Quality and Flexibility. From simple PNA synthesis to PNA conjugations or oligo chimeras. Our team of experienced chemists is available to help you arrive at the best design and synthesis strategies to meet your research goals.

Service Overviews

PNA Synthesis

PNA Conjugations

PNA Chimeras

Dual Labeled PNA

PNA Technology

Antisense Technology

Resources

	Features:
	FREE design and support from start to end
	Multi-scale from µg to grams
	Wide selection of modifications
	Purification by HPLC and characterized by mass spectrometry

Unmodified PNA

Refer to PNa’s with no labels or fluorophores attached to it, but they have the N termini free or blocked. For these PNA’s these are the options:

Unmodified PNA

Unmodified PNA with Options*

Free Amine
The PNA molecule contains a free primary amine at the N terminus. This free primary amine permits users to introduce modifications.

Addition of Lysine
Add one or more Lysines to either the the N or C-terminus of your PNA probe. Adding a Lysine introduces a positive charge into the PNA and increases water solubility and cellular uptake.

Acetylated:
The PNA molecule contain an acetyl group at the N-terminus. This blocks any further reactivity at the N terminus.

Addition of Solubility Enhancer
Solubility enhancer which do not bring any charge to molecular but enhances solubility nevertheless. Can be added at the C or N terminus.

Alkylation
The PNA molecule contains an alkyl group at the N terminus.

Linker Addition
O-Linker can also be used to increase the solubility of PNA in water. Normally, linkers are added to the N-terminus, where a user can attach its own label.

*In order to increase the solubility of your PNA and to avoid aggregation, we suggest adding one or more Lysines at the N terminus, the C terminus or both if the particular application so calls for.

Large-Scale PNA Synthesis, PNA analogs and chimeras are now available from 10 micromoles up to two grams! Call Technical Support at 800-227-0627 or write to us at biosyn@biosyn.com for more information.

PNA Modifications

For target detection, in situ detection or other applications, we can attach your PNA molecule with a variety of fluorophores including but not limited to the list below. BSI continually developing the incorporation of labelings and modifications. If a modifications or labelings not listed below, please inquire. It may be available as a product under development or we may be able to ad it to our list of R&D projects.

Modified PNA

Modified PNA with Options*

HEX, TET, JOE, Texas Red, Biotin, FITC, Dansyl, Digoxigenin, Cy3 and Cy5.

Linkage at the N-Terminus, via O-linker
(or other)

Linkage at the C-Terminus, via a Lys/Cys added as the last residue of the PNA sequence.

Please contact us for any other label specific to your needs.

PNA Analogs

With our explicit commitment to long-term continuous improvement of PNA modifications and minor bases, BSI have developed new PNA analog such as J-base which is not commonly available. If there are analogs of your interest not available, our team of chemist is available to assist you for your specific needs.

The most trusted name in Quality Custom Synthesis.