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Peptide Nucleic Acid Bioconjugates
 
The PNA molecules can be chemically linked to a variety of other chemical groups, as we detail below. These bioconjugates can be used in a variety of applications including but not limited to, Control of Gene Expression, Antisense Therapy, Cellular Uptake/Delivery, Drug/Effectors Delivery and many others.

For your convenience we have a list from which you can choose or we’ll be happy to offer suggestions.
 
Bioconjugations

Cell-Penetrating Peptide (PNA-CPP) conjugates of DNA, PNA, RNA and Peptide

Trojan Peptides, also known as Cell Penetrating Peptides (CPPs) are peptides of 10-20 residues biased with positively charged amino acid resiudes, such as Lysine and Argines are used to translocate peptides, DNA, RNA, small organics, or in general, biomolecules of your interest, across biological membranes by an energy-independent mechanism. These CPP peptides can be directly conjugated to the cargo molecule of your interest indirectly forming bio-conjugates such us peptide-peptide, peptide-DNA, peptide-RNA, peptide-PNA, peptide-oligos, etc. Contact our technical staff and we will be glad to assist you with the design, synthesis and bioconjugation of these Trojan Peptides to your specific molecule. number of chemical structures (including ones with biological activity) can be covalently linked to PNA’s for a multitude of applications.

PNA Peptide Conjuates
as peptides can be inserted at the C-terminus or N-terminus. The positioning can be as follows:

 

  Options:

PNA-Peptide Peptide1-PNA-Peptide2
Peptide–PNA PNA1-peptide-PNA2
PNA to small molecule conjugates
Compounds such us inositol, ricin,sterols, opiods etc, and in general any structure of interest can be conjugated.

Please confer with us for your specific needs or click here for price quote

 
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PNA Synthesis
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