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Custom PNA Synthesis Overview

Synthesis of peptide nucleic acids (PNA's) waholm, Berg, and Buchardt in 1991, a new, completely artificial DNA/RNA analog by replacing sugar phosphate backbons was introduced by Nielsen, Ege of natural ncueic acid with syntheic peptide backbone.

Unlike DNA or DNA analogs, thses peptide-like DNA structures have the ability to form extremly stable complexes with complementary DNA oligomers and resistance to hydrolytic reactions and, thus, not expected to be degraded inside a living cell.

The impressive property of PNA's are their ability to form extremely stable complexes with complementary DNA oligomers.

This stability suggests PNA's are superior reagents in antisense and antigene applications, and creates other uses for which sequence specific but thermally stable complexes are required.

With over 22 years of experience in synthetic nucleic acid /peptide experience, BSI has developed the expertise to deliver a diverse and broad range of custom peptide nucleic acid synthesis services. From simple PNA synthesis, PNA-bioconjugates to Oligo chimera. You can design. We can help!

Features and Capabilities

	FEE PNA design and self complimentarity check
	Multi-scale synthesis (nanomoles to millimoles)
	Comprehensive QC Analysese by HPLC and MALDI-TOP mass spectrometry
	Ability to handle small and large projects
	Explicit commitment to long-term continues improvements and cost-competitiveness
	Fast delivery with high throughput capacities

Service Overviews

PNA Synthesis

PNA Conjugations

PNA Chimeras

Dual Labeled PNA

PNA Technology

Antisense Technology

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