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Bio-Synthesis offers a complete array of fluorescent reporters and quenchers. Our product offering includes common dye modifiers such as 6-FAM, HEX and TET, as well as exotic modifications. We can directly attach fluorescent dyes to oligos at the 5'-end, 3'-end and even internal positions of an oligonucleotides during synthesis. When certain modifications (such as Digoxigenin and some fluorescent dyes) are not available for direct incorporation, cross-linking two molecules by using a specific functional group such as an amine, thiol modified oligonucleotide  with an certain cross linkers are employed. See Chemistry behind cross linking Post-synthetic chemical modifications made to an oligonucleotide result in lower yields than modifications introduced during synthesis. Further, all post  synthetic conjugation require HPLC purification. PAGE purification is not offered for post synthetic conjugation as yields are further decreased and certain modifications can be damaged during PAGE purification.

Biosynthesis Inc.
Fluorescent Labels EM Abs ε at Abs. EM Color
Pyrene 376nm 340nm 43,000  
7-Methoxycoumarin 410nm 358nm 26,000  
Cascade Blue™ 410nm 396nm 29,000
Alexa Fluor® 405 421nm 401nm 34,000
7-Aminocoumarin-X 442nm 353nm 19,000  
Alexa Fluor® 350 442nm 346nm 19,000
Pacific Blue® 451nm 416nm 36,000  
Marina Blue® 459nm 362nm 19,000
Dimethylaminocoumarin® 468nm 376nm 22,000
BODIPY 493/503™ 509nm 500nm 79,000  
BODIPY-Fl-X™ 510nm 504nm 82,000
DTAF 516nm 492nm 83,000
6-FAM (3') (Fluorescein) 516nm 496nm 74,850
6-FAM Amidite (Fluorescein) 516nm 496nm 74,850
6-FAM SE (Fluorescein) 516nm 496nm 74,850
Dansyl-X 518nm 335nm 4,200
Oregon Green 500™ 519nm 499nm 78,000
Alexa Fluor® 488 519nm 495nm 71,000
dT-FAM 520nm 492nm 74,850
dT-FAM (3') 520nm 492nm 74,850
Oregon Green 488™ 521nm 495nm 76,000
Rhodol Green™ 523nm 496nm 63,000
Oregon Green 514™ 526nm 506nm 85,000  
Rhodamine Green-X™ (mixed isomer) 528nm 503nm 74,000
NBD-X 535nm 466nm 22,000
TET Amidite 536nm 521nm 86,000
TET SE 536nm 521nm 86,000
CAL Fluor® Gold 540 541nm 522nm 74,700
Alexa Fluor® 430 541nm 434nm 16,000
Alexa Fluor® 514 542nm 517nm 80,000
2', 4', 5', 7'-Tetrabromosulfonefluorescein 544nm 529nm 89,000
BODIPY-Fl Br2™ 545nm 531nm 75,000
6-JOE 548nm 520nm 75,000
BODIPY-530/550™ 551nm 534nm 77,000  
Alexa Fluor® 532 554nm 532nm 81,000
HEX Amidite 556nm 535nm 96,000
HEX SE 556nm 535nm 96,000
Carboxyrhodamine 6G™ 557nm 524nm 108,000
CAL Fluor® Orange 560 561nm 540nm 94,000
Cy3™Amidite 562nm 550nm 150,000
Cy3™ SE 562nm 550nm 150,000
Alexa Fluor® 555 565nm 555nm 150,000
BODIPY 558/568™ 568nm 559nm 97,000
BODIPY 564/570™ 570nm 564nm 142,000
BODIPY TMR-X™ 570nm 544nm 58,000
PyMPO 570nm 415nm 26,000
Quasar 570® 570nm 547nm 115,000
Alexa Fluor® 546 573nm 556nm 104,000
dT-TAMRA 576nm 546nm 95,000  
TAMRA-X (Mixed Isomers) 576nm 546nm 82,000
TAMRA-X (Single Isomer) 576nm 546nm 82,000
Rhodamine Red-X™ 580nm 560nm 129,000
CAL Fluor® Red 590 588nm 566nm 79,000
BODIPY 576/589™ 589nm 576nm 83,000
BODIPY 581/591™ 591nm 581nm 136,000
Alexa Fluor® 568 603nm 578nm 91,300  
Texas-Red-X™ (Mixed Isomers) 603nm 583nm 116,000
Cy3.5™ Amidite 604nm 588nm 150,000
Cy3.5™ SE 604nm 588nm 150,000
Carboxy-X-Rhodamine™ (Mixed Isomers) 605nm 580nm 82,000
Carboxy-X-Rhodamine™ (Single Isomer) 605nm 580nm 82,000
CAL Fluor® Red 610 610nm 590nm 108,000
BODIPY TR-XTM 616nm 588nm 68,000
Alexa Fluor® 594 617nm 590nm 73,000
Alexa Fluor® 610 628nm 612nm 138,000  
CAL Fluor® Red 635 636nm 616nm 112,000
Alexa Fluor® 633 647nm 632nm 100,000  
Alexa Fluor® 647 665nm 650nm 239,000  
Cy5™Amidite 670nm 649nm 250,000
Cy5™ SE 670nm 649nm 250,000
Quasar 670® 670nm 644nm 187,000
Carboxynaphthofluorescein (5 & 6 mixed esters) 672nm 602nm 42,000
Alexa Fluor® 660 690nm 663nm 132,000
Cy5.5™ Amidite 694nm 675nm 250,000  
Cy5.5™SE 694nm 675nm 250,000
Alexa Fluor® 680 702nm 679nm 184,000
Alexa Fluor® 700 723nm 702nm 192,000
Alexa Fluor® 750 775nm 749nm 240,000
Price per labeling, does not include oligonucleotide synthesis and purification.


Dark Quencher EM Abs ε at Abs. Abs Color
BHQ-0 None 493 nm 34,000  
BHQ-10 None 516 nm 28,700  
BHQ-1 None 534 nm 34,000  
BHQ-2 None 579 nm 38,000  
BHQ-3 None 672 nm 42,700  

For dual labeled oligonucleotides containing a reporter and quencher molecules, please contact Life Technologies Corp. (Carlsbad CA) owners of the following related patents: 5538848;5723591;5876930;6030787 and 6258569