Bio-Synthesis offers left-handed helical L-RNA oligonucleotide synthesis at various scales. The L-RNA base can be incorporated internally or at the either end of the oligonucleotide as well as chimeric L-DNA, D-DNA , D-RNA design. These artificial oligoncueltoide are enantiomeric of natural RNA. L-RNA are Spiegelmers , mirror image of D-ribose. Like aptamers, they are able to bind target moelcule such as peptides, proteins , or low molecular weight substance at nanomolar range. They have high resistant to nuclease degradation and exhibit low antigenicity. RNA Spiegelmers offers an alternative approach for RNA based drug discovery.
Contact Bio-Synthesis for L-RNA Oligonucleotide Synthesis Service.