8-OMethyl Deoxyguanosine, 8-OMe-dG Oligonucleotide Modification

8-OMethyl Deoxyguanosine also known as 8-OMethyl dG modififed oligonucleotide has been used for the study of oxidative damage to G residues in biological systems. Such DNA damage leads to the formation of 8-oxo-G, the predominant product of G damage. 2-Aminoimidazolone and its hydrolysis product imidazolone are also major oxidation products of G. Access to these two potential lesions is not possible during oligonucleotide synthesis because they are so base-labile. We have, therefore, added the convertible base,  8-OMe-dG modication to our series of oligonucleotide modification for the study of DNA damage and repair.

Product Information

 

Product Name:

8-OMethyl Deoxyguanosine, 8-OMe-dG Oligonucleotide Modification

Category:

DNA damage and repair, convertible base

Modification Code:

[8-OMe-dG]

Chemical Formula:

C11H13N5O7P

Exact Mass:

358.06

Formula Weight:

358.23

Structure:

Purification:

HPLC or PAGE

Delivery Format:

Lyophilized

Shipping Conditions:

Room Temperature

Storage Conditions:

-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.

References/Citations:

Reference:

1.  H. Ikeda and I. Saito, J. Amer. Chem. Soc., 1999, 121, 10836-10837.

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