8-OMethyl Deoxyguanosine, 8-OMe-dG Oligonucleotide Modification
8-OMethyl Deoxyguanosine also known as 8-OMethyl dG modififed oligonucleotide has been used for the study of oxidative damage to G residues in biological systems. Such DNA damage leads to the formation of 8-oxo-G, the predominant product of G damage. 2-Aminoimidazolone and its hydrolysis product imidazolone are also major oxidation products of G. Access to these two potential lesions is not possible during oligonucleotide synthesis because they are so base-labile. We have, therefore, added the convertible base, 8-OMe-dG modication to our series of oligonucleotide modification for the study of DNA damage and repair.
Product Information
8-OMethyl Deoxyguanosine, 8-OMe-dG Oligonucleotide Modification
DNA damage and repair, convertible base
-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.
References/Citations:
Reference:
- H. Ikeda and I. Saito, J. Amer. Chem. Soc., 1999, 121, 10836-10837.
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