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Bio-Synthesis offer acridine oligonucleotide modification services. Acridine is an effective intercalating agent as well as being a lipophilic carrier molecule. Study have soen acridine can effectively stabilize heteroduplexes and inhibit gene expression1-3. Oligos containing acridine cannot be HPLC purified, nor can they be analyzed by HPLC, as they bind irreversibly to the column. Acridine is available as both a 3' and a 5' modifier. Contact us for Acridine Orange fluorescent dye oligonucleotide labeling services.
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-20°C To -70°C Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.
1. Asseline, U.; Delarue, M.; Lancelot, G.; Toulme, F.; Thuong, N. T.; Montenay-Garestier, T.; Helene, C. Proc. Natl. Acad. Sci. USA, 1984, 3297. 2. Thuong, N. T.; Asseline, U.; Roig, V.; Takasugi, M.; Helene, C. Proc. Natl. Acad. Sci. USA, 1987, 84, 5129. 3. Sun, J. S.; Asseline, U.; Rouzaud, D.; Montenay-Garestier, T.; Helene, C. Nucleic Acids Res., 1987, 15, 6149.
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