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Custom DNA & RNA Oligonucleotide Modifications

Explore 3,000+ DNA/RNA modifications with expert design support, rapid quoting, and custom solutions tailored to your assay, workflow, or therapeutic program needs.

3000+ Modifications DNA & RNA Fluorescent Labels Conjugation Handles Backbone Chemistry
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A Comprehensive Approach to Modified Oligonucleotides

DNA & RNA Modification Solutions for Research & Therapeutics

Bio-Synthesis offers one of the industry's broadest portfolios of DNA & RNA oligonucleotide modifications supporting research, diagnostics, sequencing, CRISPR, molecular detection, and therapeutic development. Our modification reference guide helps researchers identify the right chemistry, label, linker, or conjugation strategy for highly specific applications.

With over 3,000 modification options, Bio-Synthesis provides custom-modified oligonucleotides backed by expert scientific support, flexible manufacturing, and ISO/GLP/GMP-aligned workflows. From fluorescent probes and affinity tags to delivery lipids, backbone chemistry, and RNA stabilization technologies, we help researchers build oligos optimized for their program needs.

Need a modification not listed? Our scientific team can develop custom oligonucleotide solutions tailored to your sequence, assay, purification, conjugation, or therapeutic application requirements.

3000+ Modification Options ISO 9001:2015 ISO 13485:2016 45+ Years Experience U.S.A. Facility
Browse modifications by functional category

Browse Oligonucleotide Modifications by Category

Base, Sugar & Backbone Chemistry

Core nucleotide chemistry, analogs, stability improvements, and structural modification options.

DNA Base Analogs Explore → RNA Base Analogs Explore → Sugar Modifications Explore → Backbone Modifications Explore → Halogenated Bases Explore →

Terminal, Internal & RNA-Specific

Placement-specific modification options for 5′, 3′, internal, and RNA capping designs.

Terminal Caps Explore → Internal Modifications Explore → RNA Specific Capping Explore →

Conjugation, Linkers & Affinity

Functional handles for bioconjugation, delivery, immobilization, and controlled-release workflows.

Conjugation Modifications Explore → Lipid Conjugations Explore → Cross-Linking Bases Explore → Affinity Tags Explore → Enzyme Oligo Conjugates Explore → Spacer & Linkers Explore → Cleavable & Non-Cleavable Linkers Explore → Dendrimer & Brancher Explore → Reactive Handles Explore →

Fluorescent, Detection & Analytical

Labeling and signal-control options for qPCR, imaging, hybridization assays, and analytical workflows.

Fluorescence Dyes Explore → Fluorescent Bases Explore → Quenchers Explore → Chelators Explore → Intercalators Explore → Redox / Electrochemical Explore → Small Molecule Functional Tags Explore →
Modification Technologies

Custom Oligonucleotide Modification Technologies

Bio-Synthesis supports a wide range of modified oligonucleotides for molecular biology, diagnostics, qPCR probes, CRISPR oligos, sequencing, therapeutic research, and advanced analytical workflows. Available options include fluorescent oligos, affinity tags, quencher-modified probes, RNA modifications, backbone modification chemistries, and oligo conjugation handles.

Researchers can choose from modification technologies such as phosphorothioate backbone modifications, linker chemistries, biotin and other affinity labels, lipid conjugates, specialty bases, redox tags, and functional groups designed for immobilization, delivery, detection, or downstream bioconjugation.

Contact & Quote Request

Need help selecting the right oligonucleotide modification?

For the fastest review, share your oligo type, sequence length, desired modification, scale, purification requirements, and intended application. Our scientific team can recommend the most appropriate modification strategy and provide a detailed quote.
Request a Quote Speak to a Scientist
Need help before quoting?
Email: info@biosyn.com
Phone: 800-227-0627 (US/CAN)
Phone: +001-972-420-8505 (INT)

Related Services

Explore supporting oligo services for modified oligo programs, from conjugation to purification and QC.

Custom Oligo Modification by Properties Modification by Application Oligo Bioconjugation

Quote Preparation Checklist

Include sequence length, modification type, synthesis scale, purification target, delivery format, and QC requirements.

Sequence Length Modification Type Scale Purification QC Needs

Why Choose Bio-Synthesis

Trusted by biotech leaders worldwide for over 45+ years of delivering high quality, fast and scalable synthetic biology solutions.

Greetings Researchers,

Please be advised that any information, guidelines, writeups, and oral/video/graphic content on our website are intended solely as general guidelines.
It is the researcher's sole responsibility to conduct thorough research on the designs of the products intended for their experiments before submitting
their designs to Biosynthesis for review of production feasibility.
Thank you for your understanding.

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