α-Tocopherol-TEG (Tocopherol Triethylene Glycol) allows adding a lipophilic carrier to oligonucleotides. α-Tocopherol is lipophilic and non-toxic, even at high doses. Labeling oligonucleotides with α-Tocopherol-TEG is an alternative to labeling with cholesterol. Incorporating α-Tocopherol-TEG into oligonucleotides enhances their stability, solubility, and effectiveness. α-Tocopherol-TEG oligonucleotides enable the design of valuable tools in molecular biology and therapeutic development.
Key applications are:
Stabilization: α-Tocopherol helps stabilization of oligonucleotides by protecting them from oxidative damage, which is particularly important in preventing degradation of the nucleic acids during storage and handling.
Solubility Improvement: The TEG moiety enhances the solubility of oligonucleotides in aqueous solutions, making them easier to work with in many applications.
Cellular Uptake: Incorporating α-Tocopherol into oligonucleotides can potentially improve their cellular uptake. The lipophilic nature of tocopherol may facilitate membrane permeability.
Labeling and Detection: Labeling or tagging oligonucleotides with α-Tocopherol-TEG enables the design of detection and quantification assays for nucleic acids.
Therapeutic Applications: In the context of gene therapy or RNA interference, oligonucleotides modified with α-Tocopherol-TEG may exhibit enhanced efficacy and reduced toxicity.
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Product Information
-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.
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