N36, HR1, gp41 HIV Fragment

This peptide belongs to the helical region of gp41 of HIV which contains  two heptad repeat regions, N heptad and C heptad, which are highly conserved. It is believed that the heptad repeat regions in gp41 self assemble into a six-helix bundle structure (or trimer of hairpins) that likely represents a fusion-active conformation of gp41 that forms after receptor binding and is critical for membrane fusion. This structure consists of a triple stranded coiled coil formed by a trimer of N heptads. The C heptads pack in the grooves of the coiled coil in an antiparallel manner