3'-Ribouridine, 2'-5' Linked Oligonucleotide Modification

3'-ribouridine, 3'-rU Oligonucleotide modification use to substitute 2'-5' phosphodiester linkage for usual 3'-5' linkage at same or all position of an oligonucleotide. This oligonucleotide modification often use in the antisense application as ssRNA specific probes, or as ligands for affinity purification for cellular RNA. Contact Bio-Synthesis for 2-'5' linked oligonucleotide synthesis.

Product Information

 

Product Name:

3'-Ribouridine, 2'-5' Linked Oligonucleotide Modification

Alternate Name:

3'-rU

Category:

Minor Bases, Antisense, Affinity Liagand, RNA Specific Probe

Modification Code:

[3'-rU2-5]

Structure:

Purification:

HPLC or PAGE

Delivery Format:

Lyophilized

Shipping Conditions:

Room Temperature

Storage Conditions:

-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.

Related Products:

3'-Deoxyadenosine, Cordycepin,2'-5' Linked Oligonucleotide Modification

3'-Deoxycytidine, 2'-5' Linked Oligonucleotide Modification

3'-Deoxyguanosine, 2'-5' Linked Oligonucleotide Modification

3'-Deoxythymidine, 2'-5' Linked Oligonucleotide Modification

3'-Ribocytidine, 2'-5' Linked Oligonucleotide Modification

3'-Riboguanosine, 2'-5' Linked Oligonucleotide Modification

References/Citations:

References

1. Giannaris, P.A.; Damha, M.J. Oligoribonucleotides containing 2',5'-phosphodiester linkages exhibit binding selectivity for 3',5'-RNA over 3',5'-ssDNA. Nucleic Acids Res (1993), 21: 4742-4749. - 3'-rU (2'-5' linked)

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