Amino Serinol Sequence Modifier

Oligo amino serinol sequence modifier can be incorporateed at any position of an oligonucleotide. Amino modifier such as amino-dC, amino dG, amino dA and amino-dT can be added in place of a dA, dC, dG, dT during oligonucleotide synthesis. Amino Serinol sequence modifier (see image), a non-nucleosidic modifier can be incorporated "in between" two base at phosphate backbone. The primary amino group allow user to  label the oligo with a variety of different ligands or conjugated to carboxy functional groups for solid support applications.

The resulting primary amino group enables post-synthetic labeling of the oligonucleotide with a wide range of affinity, reporter, or protein moieties, depending on the application. These ligands are typically supplied as NHS esters or isothiocyanates and include biotin, digoxigenin, fluorescent dyes, quenchers, magnetic beads, and enzymes such as alkaline phosphatase. NHS ester-activated ligands react with primary amines to form stable amide bonds while releasing N-hydroxysuccinimide (NHS) as a byproduct.

Contact Bio-Synthesis for oligo amino serinol sequence modification.

Product Information

 

Product Name:

Amino Serinol Sequence Modifier

Category:

Conjugation Chemistry

Modification Code:

[Serinol Amino]

Exact Mass:

224.15

Structure:

Purification:

HPLC or PAGE

Delivery Format:

Lyophilized

Shipping Conditions:

Room Temperature

Storage Conditions:

-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.

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