Enhanced Diagnostic Tools
Controlling DNA functions using an external stimulus to quantitate at given moment can provide new tools for the analysis of
analysis of the mechanisms underlying DNA recognition and DNA-mediated bioprocesses in cell biology and pharmacology. Photo-control modified oligonucleotide react with ultraviolet or visible light has a number of advantages over other external stimuli:
Asanuma's group has demonstrated when a photo-responsive modified oligo is directly attached to DNA as a receptor, photo-regulation of the bioprocess regulated by that DNA molecule could, in principle, be achieved. Such photo-responsive DNA could also be used as a switch in a DNA-based nano-machine1,2.
Bio-Synthesis offers several photo regulation modified base oligo synthesis.
Contact Bio-Synthesis for oligo modification to block nuclease degradation.
All oligonucleotide synthesized at Bio-Synthesis is quality check by using either MALDI-TOF mass spectrometry, analytical HPLC,or polyacrylamide gel electrophoresis (PAGE) analysis. Final yields are determined using UV absorbance at OD260 In addition, we perform custom formulation and quality control tailored to meet your specific requirements.
Quality Control: Analytical HPLC, Gel eletrophoresis, and MALDI-TOF Mass Spectrometry
Delivery times: 5-7 Working days
Shipping conditions: Room temperature
Storage conditions: -20 oC to -70 oC
Oligonucleotides are stable in solution at 4 oC for up to 2 weeks. Properly reconstituted material stored at -20 oC should be stable for at least 6 months. Dried DNA (when kept at -20 oC) in a nuclease-free environment should be stable for years.