Delta sleep-inducing peptide (DSIP) is an endogenous neuropeptide that crosses the blood-brain barrier. It is associated with natural sleep and enhanced ectroencephalogram (EEG) delta rhythm.
Delta sleep-inducing peptide (DSIP) was isolated from the extracorporeal dislysate of cerebral venous blood in rabbits which was subjected to hypnogenic electrical stimulation1.
The analogs of Delta sleep-inducing peptide (DSIP) are synthesized by modification of the primary sequence of the nanopeptide. Phosphorylated DSIP, DSIP (1-4), DSIP (1-8), DSIP (2-8), DSIP (2-9), DSIP (5-9) etc are some of the analogs of DSIP.
The primary amino acid sequence of DSIP is Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu with molecular weight of 848.8 kDa.
Mode of action
The action of Delta sleep-inducing peptide (DSIP) is mediated by the activation of the serotoninergic system of the brain. It increases the activity of monoamine oxidase type A in mitochondria, the substrate of this enzyme is serotonin2.
Delta sleep-inducing peptide (DSIP) has several physiological effects in addition to its ability to promote sleep in animals. It is also involved in neuroendocrine regulation and release of anterior pituitary hormones. In rodents and humans, Delta sleep-inducing peptide (DSIP) influence in the secretion of adrenocorticotropic hormone (ACTH), luteinizing hormone (LH) and growth hormone (GH) 3,4,5,6. It also plays a role in the regulation of the circadian rhythms7.
1. Schoenenberger GA, Monnier M (1977). Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. Proc Natl Acad Sci USA, 74, 1282-1286.
2. Shandra AA, Godlevskii LS, Brusentsov AI, Petrashevich VP, Vast'yanov RS, Nikel B, Mikhaleva II (1998). Delta-sleep-inducing peptide and its analogs and the serotoninergic system in the development of anticonvulsive influences. Neurosci Behav Physiol., 28(5), 521-526.
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