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Amyloid - Forming Peptide GNNQQNY

Amyloid - Forming Peptide GNNQQNY
Sequence (1LC):
GNNQQNY
Sequence (3LC):
NH2 - Gly - Asn - Asn - Gln - Gln - Asn - Tyr - COOH
Catalog :
13933-01
Unit:
1 mg
Price/Unit:
$405  (For other quantities please Contact Us or call 972-420-8505 (USA) 800-227-0627 (INTL.) or Fax 972.420.0442)
Purity:
>95%
Format:
Each vial contains lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt
Description:
This is a heptapeptide from the N-terminal prion-determining domain of the yeast protein Sup35 that forms amyloid fibrils. The availability of its detailed atomic oligomeric structure makes it a good model for studying the early stage of aggregation. The GNNQQNY dimer forms three stable sheet structures. in-register parallel, off-register parallel, and anti-parallel. The in-register parallel dimer, which is close to the amyloid beta-sheet structure, has few interpeptide hydrogen bonds, making hydrophobic interactions more important and increasing the conformational entropy compared to the anti-parallel sheet.
Storage:
Store the peptide at -20°C. Keep container tightly
Product Usage:
This product is for research use only. Not for use in diagnostic or therapeutic procedures.
M.W.:
836.8 g/mol
Reference/Citations:
  1. Strodel, B. et al. J. Am. Chem. Soc. 129, 16005 (2007);
  2. Zhang, Z. et al. Biophys. J. 93, 1484 (2007);
  3. Zheng, J. et al. Biophys. J. 91, 824 (2006).