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2'-Deoxypseudouridine Oligonucleotide Modification

2'-deoxypseudouridine, Pseudo-dU form stable C:pseudoU-A triplets and is the most common modified nucleoside found in structural RNA, such as tRNA, rRNA, snRNA, and snoRNA (1,2).Pseudo-U modified RNA has shown to be an useful tool in RNA stucture and function study in cell. The presence of pseudouridine modified oligo has shown to enhances base-stacking, induce moderate increase in rigidity on the nearby sugar-phosphate backbone such attributes has been widely used in study of genetic mutants that lacking specific pseudouridine residues in tRNA or rRNA, in return, display slow growth rates, and fail to compete effectively with wild-type strains in mixed culture.

Product Information

 

Product Name:
2'-Deoxypseudouridine Oligonucleotide Modification

Category:

Modified DNA Bases

Modification Code:
[PS-dU]

Chemical Formula:
C9H11N2O7P

Exact Mass:
290.03

Formula Weight:
290.17

Structure:
Bio-Synthesis Inc. Oligo Structure

Purification:
HPLC or PAGE

Delivery Format:
Lyophilized

Shipping Conditions:
Room Temperature

Storage Conditions:

-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.


References/Citations:

1. Hamma, T., Ferre-D-Amare, A.R. Pseudouridine synthases. Chem. Biol. (2006), 13: 1125-1135.
2. Charette, M., Gray, M.W. Pseudouridine in RNA: what, where, how, and wny.IUBMB Life (2000), 49: 341-351.
3. Monobe, M., Arimoto-Kobayashi, S., Ando, K. beta-Pseudouridine, a beer component, reduces radiation-induced chromosome aberrations in human lymphocytes. Mut. Res—Genet. Toxicol. and Env. Mutagen. (2003), 538: 93-99. - pseudoUridine-2'deoxy (psi-dU)

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