800.227.0627

7-Deaza-dA and 7-Deaza-dG are isomers of A and G and have similar electron density. These modifed bases have been used for physical studies related to the interaction of enzymes and DNA as well as studies regarding the formation and structure of triplex DNA. 7-deaza purine monomers lack groups critical for hydrogen bonding.

7-deaza modification presence in oligos is slightly stabilizing relative to A and G. Unlike G base, 7-Deaza-dG does not lead to aggregation and G-rich oligos can be easily synthesized and isolated. 5'-fluorescen modified oligonucleotide containing 7-Deaza-dG base are much less quenched than the natural G base.

Related Products:

Contact BioSynthesis for more information regarding 7-Deaza-dA and 7-Deaza-dG

Product Information

 

Product Name:

7-Deaza-2'-deoxyadenosine, 7-Deaza-dA

Category:

Modified Bases

Modification Code:

[7-Deaza-dA]

Chemical Formula:

C11H13N4O5P

Exact Mass:

312.06

Formula Weight:

312.22

Elemental Analysis:

777

Structure:

Bio-Synthesis Inc. Oligo Structure

Purification:

HPLC or PAGE

Delivery Format:

Lyophilized

Shipping Conditions:

Room Temperature

Storage Conditions:

-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.