| Custom PNA Synthesis Overview
Synthesis of peptide
nucleic acids (PNA's) was introduce by Nielsen, Egholm,
Berg, and Buchardt in 1991, a new, completely artificial
DNA/RNA analog by replacing sugar phosphate backbone
of natural nucleic acid with synthetic peptide backbone.
Unlike DNA or DNA analogs, this peptide-like DNA structures
have the ability to form extremely stable complexes
with complementary DNA oligomers and resistance to
hydrolytic reactions and, thus, not expected to be
degraded inside a living cell.
The impressive property of PNA's are their ability
to form extremely stable complexes with complementary
DNA oligomers.
This stability suggests PNA's are superior reagents
in antisense and antigen applications, and creates
other uses for which sequence specific but thermally
stable complexes are required.
With over 22 years of experience in synthetic nucleic
acid /peptide experience, BSI has develop the
expertise in deliver a diverse and broad range custom
peptide nucleic acid synthesis services. Such as |
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