Custom PNA Synthesis PNA Chimera Peptide Nucleic Acid PNA Conjugates

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Synthesis of peptide nucleic acids (PNAs) was introduced by Nielsen, Egholm, Berg, and Buchardt in 1991 as a new, completely artificial DNA/RNA analog by replacing the sugar phosphate backbone of natural nucleic acids with a synthetic peptide backbone. Unlike DNA or DNA analogs, these peptide-like DNA structures have the ability to form extremely stable complexes with complementary DNA oligomers and resistance to hydrolytic reactions and, thus, not expected to be degraded inside a living cell. The impressive property of a PNA is its ability to form extremely stable complexes with complementary DNA oligomers. This stability suggests that PNAs are superior reagents in antisense and antigen applications, and creates other uses for which sequence specific. but thermally stable. complexes are required.

With over 20 years of experience in synthetic nucleic acid /peptide experience, BSI has developed the expertise to deliver a diverse and broad range of custom peptide nucleic acid synthesis services.

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	Unmodified PNA Synthesis		PNA Chimera
	PNA Conjugations		Dual Labeled PNA

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