| Custom PNA Synthesis Overview
Synthesis of peptide
nucleic acids (PNA's) was introduced by Nielsen, Egholm,
Berg, and Buchardt in 1991 as a new, completely artificial
DNA/RNA analog by replacing the sugar phosphate backbone
of natural nucleic acid with synthetic peptide backbone.
Unlike DNA or DNA analogs, these peptide-like DNA structures
have the ability to form extremely stable complexes
with complementary DNA oligomers and resistance to
hydrolytic reactions and, thus, not expected to be
degraded inside a living cell.
The impressive property of a PNA is their ability
to form extremely stable complexes with complementary
DNA oligomers.
This stability suggests PNA's are superior reagents
in antisense and antigen applications, and creates
other uses for which sequence specific but thermally
stable complexes are required.
With over 22 years of experience in synthetic nucleic
acid /peptide experience, BSI has developed the
expertise in our ability to deliver a diverse and broad range custom
peptide nucleic acid synthesis services. Such as |
.gif){kind=tracking}
