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Why use Special Amino Acids in peptide synthesis?

Why use Special Amino Acids in peptide synthesis?

Unnatural amino acids result in peptidomimetics that may increase in‐vivo half life and potency. d‐Amino acids are often used instead of natural l‐amino acids to increase peptide stability against proteases. Replacing the N‐H of the amide backbone with N‐Methyl is useful for destabilising the formation of secondary structure and preventing peptide aggregation.

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Greetings Researchers,

Please be advised that any information, guidelines, writeups, and oral/video/graphic content on our website are intended solely as general guidelines.
It is the researcher's sole responsibility to conduct thorough research on the designs of the products intended for their experiments before submitting
their designs to Biosynthesis for review of production feasibility.
Thank you for your understanding.

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